Cargando…

A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults

Previous research has shown beneficial effects of polyphenol-rich diets in ameliorating cognitive decline in aging adults. Here, using a randomized, double blinded, placebo-controlled chronic intervention, we investigated the effect of two proprietary blueberry formulations on cognitive performance...

Descripción completa

Detalles Bibliográficos
Autores principales: Whyte, Adrian R., Cheng, Nancy, Fromentin, Emilie, Williams, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024810/
https://www.ncbi.nlm.nih.gov/pubmed/29882843
http://dx.doi.org/10.3390/nu10060660
_version_ 1783336138492084224
author Whyte, Adrian R.
Cheng, Nancy
Fromentin, Emilie
Williams, Claire M.
author_facet Whyte, Adrian R.
Cheng, Nancy
Fromentin, Emilie
Williams, Claire M.
author_sort Whyte, Adrian R.
collection PubMed
description Previous research has shown beneficial effects of polyphenol-rich diets in ameliorating cognitive decline in aging adults. Here, using a randomized, double blinded, placebo-controlled chronic intervention, we investigated the effect of two proprietary blueberry formulations on cognitive performance in older adults; a whole wild blueberry powder at 500 mg (WBP500) and 1000 mg (WBP1000) and a purified extract at 100 mg (WBE111). One hundred and twenty-two older adults (65–80 years) were randomly allocated to a 6-month, daily regimen of either placebo or one of the three interventions. Participants were tested at baseline, 3, and 6 months on a battery of cognitive tasks targeting episodic memory, working memory and executive function, alongside mood and cardiovascular health parameters. Linear mixed model analysis found intervention to be a significant predictor of delayed word recognition on the Reys Auditory Verbal Learning Task (RAVLT), with simple contrast analysis revealing significantly better performance following WBE111 at 3 months. Similarly, performance on the Corsi Block task was predicted by treatment, with simple contrast analysis revealing a trend for better performance at 3 months following WBE111. Treatment also significantly predicted systolic blood pressure (SBP) with simple contrast analysis revealing lower SBP following intervention with WBE111 in comparison to placebo. These results indicate 3 months intervention with WBE111 can facilitate better episodic memory performance in an elderly population and reduce cardiovascular risk factors over 6 months.
format Online
Article
Text
id pubmed-6024810
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60248102018-07-08 A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults Whyte, Adrian R. Cheng, Nancy Fromentin, Emilie Williams, Claire M. Nutrients Article Previous research has shown beneficial effects of polyphenol-rich diets in ameliorating cognitive decline in aging adults. Here, using a randomized, double blinded, placebo-controlled chronic intervention, we investigated the effect of two proprietary blueberry formulations on cognitive performance in older adults; a whole wild blueberry powder at 500 mg (WBP500) and 1000 mg (WBP1000) and a purified extract at 100 mg (WBE111). One hundred and twenty-two older adults (65–80 years) were randomly allocated to a 6-month, daily regimen of either placebo or one of the three interventions. Participants were tested at baseline, 3, and 6 months on a battery of cognitive tasks targeting episodic memory, working memory and executive function, alongside mood and cardiovascular health parameters. Linear mixed model analysis found intervention to be a significant predictor of delayed word recognition on the Reys Auditory Verbal Learning Task (RAVLT), with simple contrast analysis revealing significantly better performance following WBE111 at 3 months. Similarly, performance on the Corsi Block task was predicted by treatment, with simple contrast analysis revealing a trend for better performance at 3 months following WBE111. Treatment also significantly predicted systolic blood pressure (SBP) with simple contrast analysis revealing lower SBP following intervention with WBE111 in comparison to placebo. These results indicate 3 months intervention with WBE111 can facilitate better episodic memory performance in an elderly population and reduce cardiovascular risk factors over 6 months. MDPI 2018-05-23 /pmc/articles/PMC6024810/ /pubmed/29882843 http://dx.doi.org/10.3390/nu10060660 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Whyte, Adrian R.
Cheng, Nancy
Fromentin, Emilie
Williams, Claire M.
A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
title A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
title_full A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
title_fullStr A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
title_full_unstemmed A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
title_short A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
title_sort randomized, double-blinded, placebo-controlled study to compare the safety and efficacy of low dose enhanced wild blueberry powder and wild blueberry extract (thinkblue™) in maintenance of episodic and working memory in older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024810/
https://www.ncbi.nlm.nih.gov/pubmed/29882843
http://dx.doi.org/10.3390/nu10060660
work_keys_str_mv AT whyteadrianr arandomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults
AT chengnancy arandomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults
AT fromentinemilie arandomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults
AT williamsclairem arandomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults
AT whyteadrianr randomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults
AT chengnancy randomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults
AT fromentinemilie randomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults
AT williamsclairem randomizeddoubleblindedplacebocontrolledstudytocomparethesafetyandefficacyoflowdoseenhancedwildblueberrypowderandwildblueberryextractthinkblueinmaintenanceofepisodicandworkingmemoryinolderadults