Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer

Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared w...

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Detalles Bibliográficos
Autores principales: Nishikawa, Jun, Iizasa, Hisashi, Yoshiyama, Hironori, Shimokuri, Kanami, Kobayashi, Yuki, Sasaki, Sho, Nakamura, Munetaka, Yanai, Hideo, Sakai, Kohei, Suehiro, Yutaka, Yamasaki, Takahiro, Sakaida, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024931/
https://www.ncbi.nlm.nih.gov/pubmed/29843478
http://dx.doi.org/10.3390/cancers10060167
Descripción
Sumario:Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors. EBVaGC harbors a DNA methylation phenotype, PD-L1 and PD-L2 overexpression, and frequent alterations in the PIK3CA gene. We review clinical importance of EBVaGC and discuss novel therapeutic applications for EBVaGC.

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