Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer

Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared w...

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Autores principales: Nishikawa, Jun, Iizasa, Hisashi, Yoshiyama, Hironori, Shimokuri, Kanami, Kobayashi, Yuki, Sasaki, Sho, Nakamura, Munetaka, Yanai, Hideo, Sakai, Kohei, Suehiro, Yutaka, Yamasaki, Takahiro, Sakaida, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024931/
https://www.ncbi.nlm.nih.gov/pubmed/29843478
http://dx.doi.org/10.3390/cancers10060167
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author Nishikawa, Jun
Iizasa, Hisashi
Yoshiyama, Hironori
Shimokuri, Kanami
Kobayashi, Yuki
Sasaki, Sho
Nakamura, Munetaka
Yanai, Hideo
Sakai, Kohei
Suehiro, Yutaka
Yamasaki, Takahiro
Sakaida, Isao
author_facet Nishikawa, Jun
Iizasa, Hisashi
Yoshiyama, Hironori
Shimokuri, Kanami
Kobayashi, Yuki
Sasaki, Sho
Nakamura, Munetaka
Yanai, Hideo
Sakai, Kohei
Suehiro, Yutaka
Yamasaki, Takahiro
Sakaida, Isao
author_sort Nishikawa, Jun
collection PubMed
description Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors. EBVaGC harbors a DNA methylation phenotype, PD-L1 and PD-L2 overexpression, and frequent alterations in the PIK3CA gene. We review clinical importance of EBVaGC and discuss novel therapeutic applications for EBVaGC.
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spelling pubmed-60249312018-07-09 Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer Nishikawa, Jun Iizasa, Hisashi Yoshiyama, Hironori Shimokuri, Kanami Kobayashi, Yuki Sasaki, Sho Nakamura, Munetaka Yanai, Hideo Sakai, Kohei Suehiro, Yutaka Yamasaki, Takahiro Sakaida, Isao Cancers (Basel) Review Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors. EBVaGC harbors a DNA methylation phenotype, PD-L1 and PD-L2 overexpression, and frequent alterations in the PIK3CA gene. We review clinical importance of EBVaGC and discuss novel therapeutic applications for EBVaGC. MDPI 2018-05-29 /pmc/articles/PMC6024931/ /pubmed/29843478 http://dx.doi.org/10.3390/cancers10060167 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nishikawa, Jun
Iizasa, Hisashi
Yoshiyama, Hironori
Shimokuri, Kanami
Kobayashi, Yuki
Sasaki, Sho
Nakamura, Munetaka
Yanai, Hideo
Sakai, Kohei
Suehiro, Yutaka
Yamasaki, Takahiro
Sakaida, Isao
Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer
title Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer
title_full Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer
title_fullStr Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer
title_full_unstemmed Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer
title_short Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer
title_sort clinical importance of epstein–barr virus-associated gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024931/
https://www.ncbi.nlm.nih.gov/pubmed/29843478
http://dx.doi.org/10.3390/cancers10060167
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