Cargando…
Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a disease that affects adults aged 65 years and above, and survival in this population is poor. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for these patients but is underutilized due to frequent comorbidities and perceiv...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025016/ https://www.ncbi.nlm.nih.gov/pubmed/29866998 http://dx.doi.org/10.3390/cancers10060179 |
_version_ | 1783336186759086080 |
---|---|
author | Lipof, Jodi J. Loh, Kah Poh O’Dwyer, Kristen Liesveld, Jane L. |
author_facet | Lipof, Jodi J. Loh, Kah Poh O’Dwyer, Kristen Liesveld, Jane L. |
author_sort | Lipof, Jodi J. |
collection | PubMed |
description | Acute myeloid leukemia (AML) is a disease that affects adults aged 65 years and above, and survival in this population is poor. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for these patients but is underutilized due to frequent comorbidities and perceived higher risk of treatment-related mortality and non-relapse mortality. Increasing data supports the utility of allo-HCT in fit older patients after intensive chemotherapy resulting in improvement of outcomes. With the development of reduced intensity and non-myeloablative conditioning regimens that are associated with lower rates of treatment-related toxicity and mortality, this has allowed more older patients with AML to receive allo-HCT. In this review, we provide some guidance on appropriate selection of older patients as transplant candidates, benefits and risks associated with allo-HCT, conditioning regimen choice, and stem cell transplant sources as they relate to the conduct of stem cell transplantation in older patients. |
format | Online Article Text |
id | pubmed-6025016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60250162018-07-09 Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia Lipof, Jodi J. Loh, Kah Poh O’Dwyer, Kristen Liesveld, Jane L. Cancers (Basel) Review Acute myeloid leukemia (AML) is a disease that affects adults aged 65 years and above, and survival in this population is poor. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for these patients but is underutilized due to frequent comorbidities and perceived higher risk of treatment-related mortality and non-relapse mortality. Increasing data supports the utility of allo-HCT in fit older patients after intensive chemotherapy resulting in improvement of outcomes. With the development of reduced intensity and non-myeloablative conditioning regimens that are associated with lower rates of treatment-related toxicity and mortality, this has allowed more older patients with AML to receive allo-HCT. In this review, we provide some guidance on appropriate selection of older patients as transplant candidates, benefits and risks associated with allo-HCT, conditioning regimen choice, and stem cell transplant sources as they relate to the conduct of stem cell transplantation in older patients. MDPI 2018-06-04 /pmc/articles/PMC6025016/ /pubmed/29866998 http://dx.doi.org/10.3390/cancers10060179 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lipof, Jodi J. Loh, Kah Poh O’Dwyer, Kristen Liesveld, Jane L. Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia |
title | Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia |
title_full | Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia |
title_fullStr | Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia |
title_full_unstemmed | Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia |
title_short | Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia |
title_sort | allogeneic hematopoietic cell transplantation for older adults with acute myeloid leukemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025016/ https://www.ncbi.nlm.nih.gov/pubmed/29866998 http://dx.doi.org/10.3390/cancers10060179 |
work_keys_str_mv | AT lipofjodij allogeneichematopoieticcelltransplantationforolderadultswithacutemyeloidleukemia AT lohkahpoh allogeneichematopoieticcelltransplantationforolderadultswithacutemyeloidleukemia AT odwyerkristen allogeneichematopoieticcelltransplantationforolderadultswithacutemyeloidleukemia AT liesveldjanel allogeneichematopoieticcelltransplantationforolderadultswithacutemyeloidleukemia |