Epstein Barr Virus-Associated Hodgkin Lymphoma

Classical Hodgkin lymphoma (cHL) is a distinct clinical and pathological entity with heterogeneous genetic and virological features, with regards to Epstein–Barr virus (EBV) infection. The variable association of cHL with EBV infection is probably related to the different levels of patient immunosup...

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Detalles Bibliográficos
Autores principales: Carbone, Antonino, Gloghini, Annunziata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025037/
https://www.ncbi.nlm.nih.gov/pubmed/29799516
http://dx.doi.org/10.3390/cancers10060163
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author Carbone, Antonino
Gloghini, Annunziata
author_facet Carbone, Antonino
Gloghini, Annunziata
author_sort Carbone, Antonino
collection PubMed
description Classical Hodgkin lymphoma (cHL) is a distinct clinical and pathological entity with heterogeneous genetic and virological features, with regards to Epstein–Barr virus (EBV) infection. The variable association of cHL with EBV infection is probably related to the different levels of patient immunosuppression, both locally in the tumour tissue and at the systemic level. This review paper focuses on EBV-related cHL highlighting pathogenetic and pathological features that may impact pathobiology-driven treatment for the affected patients.
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spelling pubmed-60250372018-07-09 Epstein Barr Virus-Associated Hodgkin Lymphoma Carbone, Antonino Gloghini, Annunziata Cancers (Basel) Commentary Classical Hodgkin lymphoma (cHL) is a distinct clinical and pathological entity with heterogeneous genetic and virological features, with regards to Epstein–Barr virus (EBV) infection. The variable association of cHL with EBV infection is probably related to the different levels of patient immunosuppression, both locally in the tumour tissue and at the systemic level. This review paper focuses on EBV-related cHL highlighting pathogenetic and pathological features that may impact pathobiology-driven treatment for the affected patients. MDPI 2018-05-25 /pmc/articles/PMC6025037/ /pubmed/29799516 http://dx.doi.org/10.3390/cancers10060163 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Carbone, Antonino
Gloghini, Annunziata
Epstein Barr Virus-Associated Hodgkin Lymphoma
title Epstein Barr Virus-Associated Hodgkin Lymphoma
title_full Epstein Barr Virus-Associated Hodgkin Lymphoma
title_fullStr Epstein Barr Virus-Associated Hodgkin Lymphoma
title_full_unstemmed Epstein Barr Virus-Associated Hodgkin Lymphoma
title_short Epstein Barr Virus-Associated Hodgkin Lymphoma
title_sort epstein barr virus-associated hodgkin lymphoma
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025037/
https://www.ncbi.nlm.nih.gov/pubmed/29799516
http://dx.doi.org/10.3390/cancers10060163
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