Cargando…

Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)

Women’s hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected wome...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Evelyn M. M., Tomlinson, George, Pinto, Marsha M., Berger, Claudie, Cheung, Angela M., Prior, Jerilynn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025051/
https://www.ncbi.nlm.nih.gov/pubmed/29861446
http://dx.doi.org/10.3390/ijerph15061079
_version_ 1783336194936930304
author Wong, Evelyn M. M.
Tomlinson, George
Pinto, Marsha M.
Berger, Claudie
Cheung, Angela M.
Prior, Jerilynn C.
author_facet Wong, Evelyn M. M.
Tomlinson, George
Pinto, Marsha M.
Berger, Claudie
Cheung, Angela M.
Prior, Jerilynn C.
author_sort Wong, Evelyn M. M.
collection PubMed
description Women’s hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected women aged 43–63 in the Canadian Multicentre Osteoporosis Study (CaMos), a prospective Canada-wide study; we used linear regression to assess the relationship of night sweats (VMSn) with BMD and its changes. Clinically important VMSn occurred for 12.2%. Women with VMSn were slightly younger (54.5 vs. 55.3 years, p = 0.02) and less likely to use sex steroid therapies (39.8% vs. 51.4%, p < 0.05). BMD at the lumbar spine (L1-4), femoral neck (FN) and total hip (TH) were similar between those with/without VMSn. In adjusted models, we did not find a significant association between VMSn and 2-year change in L1-4, FN and TH BMD. Age, reproductive status, weight, sex steroid therapy and smoking status were associated with 2-year change in BMD. Incident fractures over 2 years also did not differ by VMSn. Our analyses were restricted to VMSn and may not truly capture the relationship between VMS and BMD. Additional research involving VMS, bone loss and fracture incidence is needed.
format Online
Article
Text
id pubmed-6025051
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60250512018-07-16 Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos) Wong, Evelyn M. M. Tomlinson, George Pinto, Marsha M. Berger, Claudie Cheung, Angela M. Prior, Jerilynn C. Int J Environ Res Public Health Article Women’s hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected women aged 43–63 in the Canadian Multicentre Osteoporosis Study (CaMos), a prospective Canada-wide study; we used linear regression to assess the relationship of night sweats (VMSn) with BMD and its changes. Clinically important VMSn occurred for 12.2%. Women with VMSn were slightly younger (54.5 vs. 55.3 years, p = 0.02) and less likely to use sex steroid therapies (39.8% vs. 51.4%, p < 0.05). BMD at the lumbar spine (L1-4), femoral neck (FN) and total hip (TH) were similar between those with/without VMSn. In adjusted models, we did not find a significant association between VMSn and 2-year change in L1-4, FN and TH BMD. Age, reproductive status, weight, sex steroid therapy and smoking status were associated with 2-year change in BMD. Incident fractures over 2 years also did not differ by VMSn. Our analyses were restricted to VMSn and may not truly capture the relationship between VMS and BMD. Additional research involving VMS, bone loss and fracture incidence is needed. MDPI 2018-05-26 2018-06 /pmc/articles/PMC6025051/ /pubmed/29861446 http://dx.doi.org/10.3390/ijerph15061079 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wong, Evelyn M. M.
Tomlinson, George
Pinto, Marsha M.
Berger, Claudie
Cheung, Angela M.
Prior, Jerilynn C.
Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
title Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
title_full Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
title_fullStr Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
title_full_unstemmed Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
title_short Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
title_sort women’s mid-life night sweats and 2-year bone mineral density changes: a prospective, observational population-based investigation from the canadian multicentre osteoporosis study (camos)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025051/
https://www.ncbi.nlm.nih.gov/pubmed/29861446
http://dx.doi.org/10.3390/ijerph15061079
work_keys_str_mv AT wongevelynmm womensmidlifenightsweatsand2yearbonemineraldensitychangesaprospectiveobservationalpopulationbasedinvestigationfromthecanadianmulticentreosteoporosisstudycamos
AT tomlinsongeorge womensmidlifenightsweatsand2yearbonemineraldensitychangesaprospectiveobservationalpopulationbasedinvestigationfromthecanadianmulticentreosteoporosisstudycamos
AT pintomarsham womensmidlifenightsweatsand2yearbonemineraldensitychangesaprospectiveobservationalpopulationbasedinvestigationfromthecanadianmulticentreosteoporosisstudycamos
AT bergerclaudie womensmidlifenightsweatsand2yearbonemineraldensitychangesaprospectiveobservationalpopulationbasedinvestigationfromthecanadianmulticentreosteoporosisstudycamos
AT cheungangelam womensmidlifenightsweatsand2yearbonemineraldensitychangesaprospectiveobservationalpopulationbasedinvestigationfromthecanadianmulticentreosteoporosisstudycamos
AT priorjerilynnc womensmidlifenightsweatsand2yearbonemineraldensitychangesaprospectiveobservationalpopulationbasedinvestigationfromthecanadianmulticentreosteoporosisstudycamos