Cargando…

Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis

Obesity is a global disease that causes many metabolic disorders. However, effective agents for the prevention or treatment of obesity remain limited. This study investigated the anti-obesity effect and mechanism of chitosan oligosaccharide capsules (COSCs) on rats suffering from obesity induced by...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Haitao, Fu, Chuhan, Huang, Lanlan, Jiang, Yao, Deng, Xiaoyi, Guo, Jiao, Su, Zhengquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025060/
https://www.ncbi.nlm.nih.gov/pubmed/29874843
http://dx.doi.org/10.3390/md16060198
_version_ 1783336197013110784
author Pan, Haitao
Fu, Chuhan
Huang, Lanlan
Jiang, Yao
Deng, Xiaoyi
Guo, Jiao
Su, Zhengquan
author_facet Pan, Haitao
Fu, Chuhan
Huang, Lanlan
Jiang, Yao
Deng, Xiaoyi
Guo, Jiao
Su, Zhengquan
author_sort Pan, Haitao
collection PubMed
description Obesity is a global disease that causes many metabolic disorders. However, effective agents for the prevention or treatment of obesity remain limited. This study investigated the anti-obesity effect and mechanism of chitosan oligosaccharide capsules (COSCs) on rats suffering from obesity induced by a high-fat diet (HFD). After the eight-week administration of COSCs on obese rats, the body weight gain, fat/body ratio, and related biochemical indices were measured. The hepatic expressions of the leptin signal pathway (JAK2-STAT3) and gene expressions of adipogenesis-related targets were also determined. Our data showed that COSCs can regulate body weight gain, lipids, serum alanine aminotransferase, and aspartate aminotransferase, as well as upregulate the hepatic leptin receptor-b (LepRb) and the phosphorylation of JAK2 and STAT3. Meanwhile, marked increased expressions of liver sterol regulatory element-binding protein-1c, fatty acid synthase, acetyl-CoA carboxylase, 3-hydroxy-3-methylglutaryl-CoA reductase, adiponectin, adipose peroxisome proliferator-activated receptor γ, CCAAT-enhancer binding protein α, adipose differentiation-related protein, and SREBP-1c were observed. The results suggested that COSCs activate the JAK2-STAT3 signaling pathway to alleviate leptin resistance and suppress adipogenesis to reduce lipid accumulation. Thus, they can potentially be used for obesity treatment.
format Online
Article
Text
id pubmed-6025060
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60250602018-07-09 Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis Pan, Haitao Fu, Chuhan Huang, Lanlan Jiang, Yao Deng, Xiaoyi Guo, Jiao Su, Zhengquan Mar Drugs Article Obesity is a global disease that causes many metabolic disorders. However, effective agents for the prevention or treatment of obesity remain limited. This study investigated the anti-obesity effect and mechanism of chitosan oligosaccharide capsules (COSCs) on rats suffering from obesity induced by a high-fat diet (HFD). After the eight-week administration of COSCs on obese rats, the body weight gain, fat/body ratio, and related biochemical indices were measured. The hepatic expressions of the leptin signal pathway (JAK2-STAT3) and gene expressions of adipogenesis-related targets were also determined. Our data showed that COSCs can regulate body weight gain, lipids, serum alanine aminotransferase, and aspartate aminotransferase, as well as upregulate the hepatic leptin receptor-b (LepRb) and the phosphorylation of JAK2 and STAT3. Meanwhile, marked increased expressions of liver sterol regulatory element-binding protein-1c, fatty acid synthase, acetyl-CoA carboxylase, 3-hydroxy-3-methylglutaryl-CoA reductase, adiponectin, adipose peroxisome proliferator-activated receptor γ, CCAAT-enhancer binding protein α, adipose differentiation-related protein, and SREBP-1c were observed. The results suggested that COSCs activate the JAK2-STAT3 signaling pathway to alleviate leptin resistance and suppress adipogenesis to reduce lipid accumulation. Thus, they can potentially be used for obesity treatment. MDPI 2018-06-05 /pmc/articles/PMC6025060/ /pubmed/29874843 http://dx.doi.org/10.3390/md16060198 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pan, Haitao
Fu, Chuhan
Huang, Lanlan
Jiang, Yao
Deng, Xiaoyi
Guo, Jiao
Su, Zhengquan
Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis
title Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis
title_full Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis
title_fullStr Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis
title_full_unstemmed Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis
title_short Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis
title_sort anti-obesity effect of chitosan oligosaccharide capsules (coscs) in obese rats by ameliorating leptin resistance and adipogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025060/
https://www.ncbi.nlm.nih.gov/pubmed/29874843
http://dx.doi.org/10.3390/md16060198
work_keys_str_mv AT panhaitao antiobesityeffectofchitosanoligosaccharidecapsulescoscsinobeseratsbyamelioratingleptinresistanceandadipogenesis
AT fuchuhan antiobesityeffectofchitosanoligosaccharidecapsulescoscsinobeseratsbyamelioratingleptinresistanceandadipogenesis
AT huanglanlan antiobesityeffectofchitosanoligosaccharidecapsulescoscsinobeseratsbyamelioratingleptinresistanceandadipogenesis
AT jiangyao antiobesityeffectofchitosanoligosaccharidecapsulescoscsinobeseratsbyamelioratingleptinresistanceandadipogenesis
AT dengxiaoyi antiobesityeffectofchitosanoligosaccharidecapsulescoscsinobeseratsbyamelioratingleptinresistanceandadipogenesis
AT guojiao antiobesityeffectofchitosanoligosaccharidecapsulescoscsinobeseratsbyamelioratingleptinresistanceandadipogenesis
AT suzhengquan antiobesityeffectofchitosanoligosaccharidecapsulescoscsinobeseratsbyamelioratingleptinresistanceandadipogenesis