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Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis
This study aimed to determine if short-term exposure to particulate matter (PM(2.5)) and ozone (O(3)) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025101/ https://www.ncbi.nlm.nih.gov/pubmed/29861437 http://dx.doi.org/10.3390/ijerph15061077 |
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author | Pirozzi, Cheryl S. Mendoza, Daniel L. Xu, Yizhe Zhang, Yue Scholand, Mary Beth Baughman, Robert P. |
author_facet | Pirozzi, Cheryl S. Mendoza, Daniel L. Xu, Yizhe Zhang, Yue Scholand, Mary Beth Baughman, Robert P. |
author_sort | Pirozzi, Cheryl S. |
collection | PubMed |
description | This study aimed to determine if short-term exposure to particulate matter (PM(2.5)) and ozone (O(3)) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM(2.5) and O(3) estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline > 10%) and questionnaire outcomes (Leicester cough questionnaire (LCQ), Saint George Respiratory Questionnaire (SGRQ), and King’s Sarcoidosis Questionnaire (KSQ)) using generalized linear mixed effect models. PM(2.5) level averaged over 14 days was associated with lower KSQ general health status (score change −6.60 per interquartile range (IQR) PM(2.5) increase). PM(2.5) level averaged over 10 and 14 days was associated with lower KSQ lung specific health status (score change −6.93 and −6.91, respectively). PM(2.5) levels were not associated with FEV(1), FVC, episodes of FEV(1) decline > 10%, or respiratory symptoms measured by SGRQ or LCQ. Ozone exposure was not associated with any health outcomes. In this small cohort of patients with fibrotic sarcoidosis, PM(2.5) exposure was associated with increased severity of respiratory and quality of life symptoms. |
format | Online Article Text |
id | pubmed-6025101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60251012018-07-16 Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis Pirozzi, Cheryl S. Mendoza, Daniel L. Xu, Yizhe Zhang, Yue Scholand, Mary Beth Baughman, Robert P. Int J Environ Res Public Health Article This study aimed to determine if short-term exposure to particulate matter (PM(2.5)) and ozone (O(3)) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM(2.5) and O(3) estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline > 10%) and questionnaire outcomes (Leicester cough questionnaire (LCQ), Saint George Respiratory Questionnaire (SGRQ), and King’s Sarcoidosis Questionnaire (KSQ)) using generalized linear mixed effect models. PM(2.5) level averaged over 14 days was associated with lower KSQ general health status (score change −6.60 per interquartile range (IQR) PM(2.5) increase). PM(2.5) level averaged over 10 and 14 days was associated with lower KSQ lung specific health status (score change −6.93 and −6.91, respectively). PM(2.5) levels were not associated with FEV(1), FVC, episodes of FEV(1) decline > 10%, or respiratory symptoms measured by SGRQ or LCQ. Ozone exposure was not associated with any health outcomes. In this small cohort of patients with fibrotic sarcoidosis, PM(2.5) exposure was associated with increased severity of respiratory and quality of life symptoms. MDPI 2018-05-26 2018-06 /pmc/articles/PMC6025101/ /pubmed/29861437 http://dx.doi.org/10.3390/ijerph15061077 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pirozzi, Cheryl S. Mendoza, Daniel L. Xu, Yizhe Zhang, Yue Scholand, Mary Beth Baughman, Robert P. Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis |
title | Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis |
title_full | Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis |
title_fullStr | Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis |
title_full_unstemmed | Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis |
title_short | Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis |
title_sort | short-term particulate air pollution exposure is associated with increased severity of respiratory and quality of life symptoms in patients with fibrotic sarcoidosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025101/ https://www.ncbi.nlm.nih.gov/pubmed/29861437 http://dx.doi.org/10.3390/ijerph15061077 |
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