CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-β Signaling in Prostate Cancer

The DKK3 gene encodes a secreted protein, Dkk-3, that inhibits prostate tumor growth and metastasis. DKK3 is downregulated by promoter methylation in many types of cancer, including prostate cancer. Gene silencing studies have shown that Dkk-3 maintains normal prostate epithelial cell homeostasis by...

Descripción completa

Detalles Bibliográficos
Autores principales: Kardooni, Hoda, Gonzalez-Gualda, Estela, Stylianakis, Emmanouil, Saffaran, Sina, Waxman, Jonathan, Kypta, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025141/
https://www.ncbi.nlm.nih.gov/pubmed/29843383
http://dx.doi.org/10.3390/cancers10060165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025141/
https://www.ncbi.nlm.nih.gov/pubmed/29843383
http://dx.doi.org/10.3390/cancers10060165

Ejemplares similares