Cargando…

CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-β Signaling in Prostate Cancer

The DKK3 gene encodes a secreted protein, Dkk-3, that inhibits prostate tumor growth and metastasis. DKK3 is downregulated by promoter methylation in many types of cancer, including prostate cancer. Gene silencing studies have shown that Dkk-3 maintains normal prostate epithelial cell homeostasis by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kardooni, Hoda, Gonzalez-Gualda, Estela, Stylianakis, Emmanouil, Saffaran, Sina, Waxman, Jonathan, Kypta, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025141/ https://www.ncbi.nlm.nih.gov/pubmed/29843383 http://dx.doi.org/10.3390/cancers10060165

Ejemplares similares

Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1
por: Al Shareef, Zainab, et al.
Publicado: (2018)

DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
por: Fezza, Maha, et al.
Publicado: (2019)

TGFβ1 Suppressed Matrix Mineralization of Osteoblasts Differentiation by Regulating SMURF1–C/EBPβ–DKK1 Axis
por: Nam, Bora, et al.
Publicado: (2020)

DKK-1 in prostate cancer diagnosis and follow up
por: D’Amelio, Patrizia, et al.
Publicado: (2014)

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
por: Murillo-Garzón, Virginia, et al.
Publicado: (2018)

Distinct roles of DKK1 and DKK2 in tumor angiogenesis
por: Park, Hongryeol, et al.
Publicado: (2013)

Methylation Patterns of DKK1, DKK3 and GSK3β Are Accompanied with Different Expression Levels in Human Astrocytoma
por: Kafka, Anja, et al.
Publicado: (2021)

Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer
por: Kawano, Y, et al.
Publicado: (2009)

Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins
por: Patel, Saleha, et al.
Publicado: (2018)

Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice
por: Liu, Quan-Wen, et al.
Publicado: (2022)

BAC-Dkk3-EGFP Transgenic Mouse: An In Vivo Analytical Tool for Dkk3 Expression
por: Muranishi, Yuki, et al.
Publicado: (2012)

microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer
por: Ueno, K, et al.
Publicado: (2013)

Single nucleotide polymorphisms in DKK3 gene are associated with prostate cancer risk and progression
por: Kim, Min Su, et al.
Publicado: (2015)

Methylation Assessment of Two DKK2 and DKK4 Genes in Oral Squamous Cell Carcinoma Patients
por: KHEIRANDISH, Sedigheh, et al.
Publicado: (2020)

Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
por: Uysal-Onganer, Pinar, et al.
Publicado: (2010)

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
por: Shailesh, Harshita, et al.
Publicado: (2021)

Epigenetic Silencing of DKK3 in Medulloblastoma
por: Valdora, Francesca, et al.
Publicado: (2013)

Drug Discovery of DKK1 Inhibitors
por: Jiang, Hewen, et al.
Publicado: (2022)

A screen for transcription factor targets of Glycogen Synthase Kinase-3 highlights an inverse correlation of NFκB and Androgen Receptor Signaling in Prostate Cancer
por: Campa, Victor M., et al.
Publicado: (2014)

DKK3’s protective role in prostate cancer is partly due to the modulation of immune-related pathways
por: Shareef, Zainab Al, et al.
Publicado: (2023)

TGF-β mediated DNA methylation in prostate cancer
por: Lee, Chung, et al.
Publicado: (2012)

Mechanisms navigating the TGF-β pathway in prostate cancer
por: Cao, Zheng, et al.
Publicado: (2015)

Role of DKK4 in Tumorigenesis and Tumor Progression
por: Cai, Xinjia, et al.
Publicado: (2018)

The role of Sfrp and DKK proteins in cardiomyocyte development
por: Hsueh, Ying‐Chang, et al.
Publicado: (2021)

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
por: Wang, Xiao, et al.
Publicado: (2022)

miR-1303 promotes the proliferation, migration and invasion of prostate cancer cells through regulating the Wnt/β-catenin pathway by targeting DKK3
por: Liu, Bo, et al.
Publicado: (2019)

miR-1290 contributes to oncogenesis and angiogenesis via targeting of THBS1, DKK3 and, SCAI
por: Soheilifar, Mohammad Hasan, et al.
Publicado: (2022)

Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways
por: Liu, Chi-Ming, et al.
Publicado: (2023)

DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN‐01
por: Jarman, Edward J., et al.
Publicado: (2022)

Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
por: Wang, Xiao, et al.
Publicado: (2018)

Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
por: Batool, Tahira, et al.
Publicado: (2017)

Del-1, an Endogenous Inhibitor of TGF-β Activation, Attenuates Fibrosis
por: Kim, Dong-Young, et al.
Publicado: (2020)

Lin28a attenuates TGF-β-induced renal fibrosis
por: Jung, Gwon-Soo, et al.
Publicado: (2020)

TGFβ signaling limits lineage plasticity in prostate cancer
por: Hao, Yi, et al.
Publicado: (2018)

Is the Bench Getting Closer to the Bedside in the War on Cancer? A Quick Look at Prostate Cancer
por: Kypta, Robert, et al.
Publicado: (2012)

Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma
por: Dun, Xiaoyi, et al.
Publicado: (2010)

Echogenic, Ultrasound-Sensitive Chitosan Nanodroplets for Spatiotemporally Controlled DKK-2 Gene Delivery to Prostate Cancer Cells
por: Liu, Xinxin, et al.
Publicado: (2021)

ZBTB38 suppresses prostate cancer cell proliferation and migration via directly promoting DKK1 expression
por: Ding, Guanxiong, et al.
Publicado: (2021)

Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools
por: Johansson, Marie, et al.
Publicado: (2019)

Expression of DKK1 in Endometrial Endometrioid Carcinoma and Its Correlation with Wnt/β-catenin Signalling Pathway
por: Das, Abhijit, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5hmnn6e3l7a6qusbl3s9olv5ef