Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer

Colorectal cancer (CRC) is one of the most common cancers, for which combination treatment of chemotherapy is employed. However, most patients develop drug resistance during the course of treatment. To clarify the mechanisms of drug resistance, various research models have been developed. Recently,...

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Detalles Bibliográficos
Autores principales: Elbadawy, Mohamed, Usui, Tatsuya, Yamawaki, Hideyuki, Sasaki, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025190/
https://www.ncbi.nlm.nih.gov/pubmed/29843359
http://dx.doi.org/10.3390/cancers10060164
Descripción
Sumario:Colorectal cancer (CRC) is one of the most common cancers, for which combination treatment of chemotherapy is employed. However, most patients develop drug resistance during the course of treatment. To clarify the mechanisms of drug resistance, various research models have been developed. Recently, we established a human CRC patients-derived three-dimensional (3D) culture system using an air-liquid interface organoid method. It contained numerous cancer stem cells and showed resistance to 5-fluorouracil and Irinotecan. In this review, we introduce conventional and our established models for studying drug resistance in CRC.

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