Cargando…

Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients

This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Damascena, Lecidamia Cristina Leite, de Lucena, Nyellisonn Nando Nóbrega, Ribeiro, Isabella Lima Arrais, de Araujo, Tarciana Liberal Pereira, de Castro, Ricardo Dias, Bonan, Paulo Rogério Ferreti, Lima Neto, Eufrásio de Andrade, de Araújo Filho, Luiz Medeiros, Valença, Ana Maria Gondim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025254/
https://www.ncbi.nlm.nih.gov/pubmed/29865201
http://dx.doi.org/10.3390/ijerph15061153
_version_ 1783336237837320192
author Damascena, Lecidamia Cristina Leite
de Lucena, Nyellisonn Nando Nóbrega
Ribeiro, Isabella Lima Arrais
de Araujo, Tarciana Liberal Pereira
de Castro, Ricardo Dias
Bonan, Paulo Rogério Ferreti
Lima Neto, Eufrásio de Andrade
de Araújo Filho, Luiz Medeiros
Valença, Ana Maria Gondim
author_facet Damascena, Lecidamia Cristina Leite
de Lucena, Nyellisonn Nando Nóbrega
Ribeiro, Isabella Lima Arrais
de Araujo, Tarciana Liberal Pereira
de Castro, Ricardo Dias
Bonan, Paulo Rogério Ferreti
Lima Neto, Eufrásio de Andrade
de Araújo Filho, Luiz Medeiros
Valença, Ana Maria Gondim
author_sort Damascena, Lecidamia Cristina Leite
collection PubMed
description This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the Modified Oral Assessment Guide criteria, and the data were collected from the patients’ records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race (“pardo”) (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis (p-value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis.
format Online
Article
Text
id pubmed-6025254
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60252542018-07-16 Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients Damascena, Lecidamia Cristina Leite de Lucena, Nyellisonn Nando Nóbrega Ribeiro, Isabella Lima Arrais de Araujo, Tarciana Liberal Pereira de Castro, Ricardo Dias Bonan, Paulo Rogério Ferreti Lima Neto, Eufrásio de Andrade de Araújo Filho, Luiz Medeiros Valença, Ana Maria Gondim Int J Environ Res Public Health Article This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the Modified Oral Assessment Guide criteria, and the data were collected from the patients’ records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race (“pardo”) (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis (p-value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis. MDPI 2018-06-01 2018-06 /pmc/articles/PMC6025254/ /pubmed/29865201 http://dx.doi.org/10.3390/ijerph15061153 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Damascena, Lecidamia Cristina Leite
de Lucena, Nyellisonn Nando Nóbrega
Ribeiro, Isabella Lima Arrais
de Araujo, Tarciana Liberal Pereira
de Castro, Ricardo Dias
Bonan, Paulo Rogério Ferreti
Lima Neto, Eufrásio de Andrade
de Araújo Filho, Luiz Medeiros
Valença, Ana Maria Gondim
Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
title Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
title_full Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
title_fullStr Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
title_full_unstemmed Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
title_short Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
title_sort factors contributing to the duration of chemotherapy-induced severe oral mucositis in oncopediatric patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025254/
https://www.ncbi.nlm.nih.gov/pubmed/29865201
http://dx.doi.org/10.3390/ijerph15061153
work_keys_str_mv AT damascenalecidamiacristinaleite factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT delucenanyellisonnnandonobrega factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT ribeiroisabellalimaarrais factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT dearaujotarcianaliberalpereira factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT decastroricardodias factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT bonanpaulorogerioferreti factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT limanetoeufrasiodeandrade factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT dearaujofilholuizmedeiros factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients
AT valencaanamariagondim factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients