Cargando…
Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy pr...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025254/ https://www.ncbi.nlm.nih.gov/pubmed/29865201 http://dx.doi.org/10.3390/ijerph15061153 |
_version_ | 1783336237837320192 |
---|---|
author | Damascena, Lecidamia Cristina Leite de Lucena, Nyellisonn Nando Nóbrega Ribeiro, Isabella Lima Arrais de Araujo, Tarciana Liberal Pereira de Castro, Ricardo Dias Bonan, Paulo Rogério Ferreti Lima Neto, Eufrásio de Andrade de Araújo Filho, Luiz Medeiros Valença, Ana Maria Gondim |
author_facet | Damascena, Lecidamia Cristina Leite de Lucena, Nyellisonn Nando Nóbrega Ribeiro, Isabella Lima Arrais de Araujo, Tarciana Liberal Pereira de Castro, Ricardo Dias Bonan, Paulo Rogério Ferreti Lima Neto, Eufrásio de Andrade de Araújo Filho, Luiz Medeiros Valença, Ana Maria Gondim |
author_sort | Damascena, Lecidamia Cristina Leite |
collection | PubMed |
description | This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the Modified Oral Assessment Guide criteria, and the data were collected from the patients’ records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race (“pardo”) (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis (p-value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis. |
format | Online Article Text |
id | pubmed-6025254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60252542018-07-16 Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients Damascena, Lecidamia Cristina Leite de Lucena, Nyellisonn Nando Nóbrega Ribeiro, Isabella Lima Arrais de Araujo, Tarciana Liberal Pereira de Castro, Ricardo Dias Bonan, Paulo Rogério Ferreti Lima Neto, Eufrásio de Andrade de Araújo Filho, Luiz Medeiros Valença, Ana Maria Gondim Int J Environ Res Public Health Article This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the Modified Oral Assessment Guide criteria, and the data were collected from the patients’ records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race (“pardo”) (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis (p-value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis. MDPI 2018-06-01 2018-06 /pmc/articles/PMC6025254/ /pubmed/29865201 http://dx.doi.org/10.3390/ijerph15061153 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Damascena, Lecidamia Cristina Leite de Lucena, Nyellisonn Nando Nóbrega Ribeiro, Isabella Lima Arrais de Araujo, Tarciana Liberal Pereira de Castro, Ricardo Dias Bonan, Paulo Rogério Ferreti Lima Neto, Eufrásio de Andrade de Araújo Filho, Luiz Medeiros Valença, Ana Maria Gondim Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients |
title | Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients |
title_full | Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients |
title_fullStr | Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients |
title_full_unstemmed | Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients |
title_short | Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients |
title_sort | factors contributing to the duration of chemotherapy-induced severe oral mucositis in oncopediatric patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025254/ https://www.ncbi.nlm.nih.gov/pubmed/29865201 http://dx.doi.org/10.3390/ijerph15061153 |
work_keys_str_mv | AT damascenalecidamiacristinaleite factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT delucenanyellisonnnandonobrega factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT ribeiroisabellalimaarrais factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT dearaujotarcianaliberalpereira factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT decastroricardodias factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT bonanpaulorogerioferreti factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT limanetoeufrasiodeandrade factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT dearaujofilholuizmedeiros factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients AT valencaanamariagondim factorscontributingtothedurationofchemotherapyinducedsevereoralmucositisinoncopediatricpatients |