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Oncolytic Viruses for Multiple Myeloma Therapy
Although recent treatment advances have improved outcomes for patients with multiple myeloma (MM), the disease frequently becomes refractory to current therapies. MM thus remains incurable for most patients and new therapies are urgently needed. Oncolytic viruses are a promising new class of therape...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025383/ https://www.ncbi.nlm.nih.gov/pubmed/29903988 http://dx.doi.org/10.3390/cancers10060198 |
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author | Calton, Christine M. Kelly, Kevin R. Anwer, Faiz Carew, Jennifer S. Nawrocki, Steffan T. |
author_facet | Calton, Christine M. Kelly, Kevin R. Anwer, Faiz Carew, Jennifer S. Nawrocki, Steffan T. |
author_sort | Calton, Christine M. |
collection | PubMed |
description | Although recent treatment advances have improved outcomes for patients with multiple myeloma (MM), the disease frequently becomes refractory to current therapies. MM thus remains incurable for most patients and new therapies are urgently needed. Oncolytic viruses are a promising new class of therapeutics that provide tumor-targeted therapy by specifically infecting and replicating within cancerous cells. Oncolytic therapy yields results from both direct killing of malignant cells and induction of an anti-tumor immune response. In this review, we will describe oncolytic viruses that are being tested for MM therapy with a focus on those agents that have advanced into clinical trials. |
format | Online Article Text |
id | pubmed-6025383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60253832018-07-09 Oncolytic Viruses for Multiple Myeloma Therapy Calton, Christine M. Kelly, Kevin R. Anwer, Faiz Carew, Jennifer S. Nawrocki, Steffan T. Cancers (Basel) Review Although recent treatment advances have improved outcomes for patients with multiple myeloma (MM), the disease frequently becomes refractory to current therapies. MM thus remains incurable for most patients and new therapies are urgently needed. Oncolytic viruses are a promising new class of therapeutics that provide tumor-targeted therapy by specifically infecting and replicating within cancerous cells. Oncolytic therapy yields results from both direct killing of malignant cells and induction of an anti-tumor immune response. In this review, we will describe oncolytic viruses that are being tested for MM therapy with a focus on those agents that have advanced into clinical trials. MDPI 2018-06-14 /pmc/articles/PMC6025383/ /pubmed/29903988 http://dx.doi.org/10.3390/cancers10060198 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Calton, Christine M. Kelly, Kevin R. Anwer, Faiz Carew, Jennifer S. Nawrocki, Steffan T. Oncolytic Viruses for Multiple Myeloma Therapy |
title | Oncolytic Viruses for Multiple Myeloma Therapy |
title_full | Oncolytic Viruses for Multiple Myeloma Therapy |
title_fullStr | Oncolytic Viruses for Multiple Myeloma Therapy |
title_full_unstemmed | Oncolytic Viruses for Multiple Myeloma Therapy |
title_short | Oncolytic Viruses for Multiple Myeloma Therapy |
title_sort | oncolytic viruses for multiple myeloma therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025383/ https://www.ncbi.nlm.nih.gov/pubmed/29903988 http://dx.doi.org/10.3390/cancers10060198 |
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