Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056

Nine new angucycline glycosides designated urdamycins N1–N9 (1–9), together with two known congener urdamycins A (10) and B (11), were obtained from a mangrove-derived Streptomyces diastaticus subsp. SCSIO GJ056. The structures of new compounds were elucidated on the basis of extensive spectroscopic...

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Detalles Bibliográficos
Autores principales: Gui, Chun, Liu, Yena, Zhou, Zhenbin, Zhang, Shanwen, Hu, Yunfeng, Gu, Yu-Cheng, Huang, Hongbo, Ju, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025406/
https://www.ncbi.nlm.nih.gov/pubmed/29843358
http://dx.doi.org/10.3390/md16060185
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author Gui, Chun
Liu, Yena
Zhou, Zhenbin
Zhang, Shanwen
Hu, Yunfeng
Gu, Yu-Cheng
Huang, Hongbo
Ju, Jianhua
author_facet Gui, Chun
Liu, Yena
Zhou, Zhenbin
Zhang, Shanwen
Hu, Yunfeng
Gu, Yu-Cheng
Huang, Hongbo
Ju, Jianhua
author_sort Gui, Chun
collection PubMed
description Nine new angucycline glycosides designated urdamycins N1–N9 (1–9), together with two known congener urdamycins A (10) and B (11), were obtained from a mangrove-derived Streptomyces diastaticus subsp. SCSIO GJ056. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis. The absolute configurations of 6–9 were assigned by electronic circular dichroism calculation method. Urdamycins N7 (7) and N8 (8) represent the first naturally occurring (5R, 6R)-angucycline glycosides, which are diastereomers of urdamycins N6 (6) and N9 (9), respectively.
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spelling pubmed-60254062018-07-09 Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056 Gui, Chun Liu, Yena Zhou, Zhenbin Zhang, Shanwen Hu, Yunfeng Gu, Yu-Cheng Huang, Hongbo Ju, Jianhua Mar Drugs Communication Nine new angucycline glycosides designated urdamycins N1–N9 (1–9), together with two known congener urdamycins A (10) and B (11), were obtained from a mangrove-derived Streptomyces diastaticus subsp. SCSIO GJ056. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis. The absolute configurations of 6–9 were assigned by electronic circular dichroism calculation method. Urdamycins N7 (7) and N8 (8) represent the first naturally occurring (5R, 6R)-angucycline glycosides, which are diastereomers of urdamycins N6 (6) and N9 (9), respectively. MDPI 2018-05-28 /pmc/articles/PMC6025406/ /pubmed/29843358 http://dx.doi.org/10.3390/md16060185 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gui, Chun
Liu, Yena
Zhou, Zhenbin
Zhang, Shanwen
Hu, Yunfeng
Gu, Yu-Cheng
Huang, Hongbo
Ju, Jianhua
Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056
title Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056
title_full Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056
title_fullStr Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056
title_full_unstemmed Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056
title_short Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056
title_sort angucycline glycosides from mangrove-derived streptomyces diastaticus subsp. scsio gj056
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025406/
https://www.ncbi.nlm.nih.gov/pubmed/29843358
http://dx.doi.org/10.3390/md16060185
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