Cargando…
Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology
The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cati...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025450/ https://www.ncbi.nlm.nih.gov/pubmed/29914130 http://dx.doi.org/10.3390/cells7060062 |
_version_ | 1783336283924332544 |
---|---|
author | Wang, Chen Naruse, Keiji Takahashi, Ken |
author_facet | Wang, Chen Naruse, Keiji Takahashi, Ken |
author_sort | Wang, Chen |
collection | PubMed |
description | The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also plays a key role in cardiovascular pathophysiology; for example, a mutation in the TRPM4 channel leads to cardiac conduction disease. Recently, it has been suggested that the TRPM4 channel is also involved in the development of cardiac ischemia-reperfusion injury, which causes myocardial infarction. In the present review, we discuss the physiological function of the TRPM4 channel, and assess its role in cardiovascular pathophysiology. |
format | Online Article Text |
id | pubmed-6025450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60254502018-07-09 Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology Wang, Chen Naruse, Keiji Takahashi, Ken Cells Review The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also plays a key role in cardiovascular pathophysiology; for example, a mutation in the TRPM4 channel leads to cardiac conduction disease. Recently, it has been suggested that the TRPM4 channel is also involved in the development of cardiac ischemia-reperfusion injury, which causes myocardial infarction. In the present review, we discuss the physiological function of the TRPM4 channel, and assess its role in cardiovascular pathophysiology. MDPI 2018-06-15 /pmc/articles/PMC6025450/ /pubmed/29914130 http://dx.doi.org/10.3390/cells7060062 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Chen Naruse, Keiji Takahashi, Ken Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology |
title | Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology |
title_full | Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology |
title_fullStr | Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology |
title_full_unstemmed | Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology |
title_short | Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology |
title_sort | role of the trpm4 channel in cardiovascular physiology and pathophysiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025450/ https://www.ncbi.nlm.nih.gov/pubmed/29914130 http://dx.doi.org/10.3390/cells7060062 |
work_keys_str_mv | AT wangchen roleofthetrpm4channelincardiovascularphysiologyandpathophysiology AT narusekeiji roleofthetrpm4channelincardiovascularphysiologyandpathophysiology AT takahashiken roleofthetrpm4channelincardiovascularphysiologyandpathophysiology |