Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR

The absolute configuration of retroflexanone (1) and a closely related phlorogluinol (2) was established using the advanced Mosher method and by application of HPLC-NMR. HPLC-NMR permitted a small scale Mosher method analysis to be carried out on these unstable phloroglucinols.

Detalles Bibliográficos
Autores principales: Singleton, Caleb, Brkljača, Robert, Urban, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025468/
https://www.ncbi.nlm.nih.gov/pubmed/29895761
http://dx.doi.org/10.3390/md16060205
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author Singleton, Caleb
Brkljača, Robert
Urban, Sylvia
author_facet Singleton, Caleb
Brkljača, Robert
Urban, Sylvia
author_sort Singleton, Caleb
collection PubMed
description The absolute configuration of retroflexanone (1) and a closely related phlorogluinol (2) was established using the advanced Mosher method and by application of HPLC-NMR. HPLC-NMR permitted a small scale Mosher method analysis to be carried out on these unstable phloroglucinols.
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spelling pubmed-60254682018-07-09 Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR Singleton, Caleb Brkljača, Robert Urban, Sylvia Mar Drugs Article The absolute configuration of retroflexanone (1) and a closely related phlorogluinol (2) was established using the advanced Mosher method and by application of HPLC-NMR. HPLC-NMR permitted a small scale Mosher method analysis to be carried out on these unstable phloroglucinols. MDPI 2018-06-12 /pmc/articles/PMC6025468/ /pubmed/29895761 http://dx.doi.org/10.3390/md16060205 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Singleton, Caleb
Brkljača, Robert
Urban, Sylvia
Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR
title Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR
title_full Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR
title_fullStr Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR
title_full_unstemmed Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR
title_short Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR
title_sort absolute configuration determination of retroflexanone using the advanced mosher method and application of hplc-nmr
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025468/
https://www.ncbi.nlm.nih.gov/pubmed/29895761
http://dx.doi.org/10.3390/md16060205
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