Cargando…
Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target
Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy. Here, we discuss how PAGE4, a protein which appears to act...
Autores principales: | Salgia, Ravi, Jolly, Mohit Kumar, Dorff, Tanya, Lau, Clayton, Weninger, Keith, Orban, John, Kulkarni, Prakash |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025510/ https://www.ncbi.nlm.nih.gov/pubmed/29914187 http://dx.doi.org/10.3390/jcm7060156 |
Ejemplares similares
-
Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level
por: Lin, Xingcheng, et al.
Publicado: (2019) -
Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer
por: Kulkarni, Prakash, et al.
Publicado: (2016) -
Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity
por: Jolly, Mohit Kumar, et al.
Publicado: (2018) -
Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-Genetic Heterogeneity in Prostate Cancer Cells
por: Singh, Divyoj, et al.
Publicado: (2021) -
Intrinsically disordered proteins and conformational noise: The hypothesis a decade later
por: Kulkarni, Prakash, et al.
Publicado: (2023)