Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na(+), K(+) and Ca(2+). In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5. We review evidence for the formation of different TRPC1/4/5 tetramers, give an overview of rec...

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Detalles Bibliográficos
Autores principales: Minard, Aisling, Bauer, Claudia C., Wright, David J., Rubaiy, Hussein N., Muraki, Katsuhiko, Beech, David J., Bon, Robin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025525/
https://www.ncbi.nlm.nih.gov/pubmed/29865154
http://dx.doi.org/10.3390/cells7060052

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