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Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target
p53 missense mutant alleles are present in nearly 40% of all human tumors. Such mutated alleles generate aberrant proteins that not only lose their tumor-suppressive functions but also frequently act as driver oncogenes, which promote malignant progression, invasion, metastasis, and chemoresistance,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025530/ https://www.ncbi.nlm.nih.gov/pubmed/29875343 http://dx.doi.org/10.3390/cancers10060188 |