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Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025555/ https://www.ncbi.nlm.nih.gov/pubmed/29848950 http://dx.doi.org/10.3390/cancers10060168 |
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author | Murray, James T. Tee, Andrew R. |
author_facet | Murray, James T. Tee, Andrew R. |
author_sort | Murray, James T. |
collection | PubMed |
description | This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special issue also describes a wider array of mTOR-driven biological processes that cancer cells benefit from, including autophagy, cell cycle control, metabolic transformation, angiogenic signaling, and anabolic processes such as nucleotide biosynthesis and ribosomal biogenesis. Other areas of mTOR signaling covered in these reviews delve into cell migration, inflammation, and regulation of transcription factors linked to cancer progression. |
format | Online Article Text |
id | pubmed-6025555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60255552018-07-09 Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting Murray, James T. Tee, Andrew R. Cancers (Basel) Editorial This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special issue also describes a wider array of mTOR-driven biological processes that cancer cells benefit from, including autophagy, cell cycle control, metabolic transformation, angiogenic signaling, and anabolic processes such as nucleotide biosynthesis and ribosomal biogenesis. Other areas of mTOR signaling covered in these reviews delve into cell migration, inflammation, and regulation of transcription factors linked to cancer progression. MDPI 2018-05-30 /pmc/articles/PMC6025555/ /pubmed/29848950 http://dx.doi.org/10.3390/cancers10060168 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Murray, James T. Tee, Andrew R. Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting |
title | Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting |
title_full | Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting |
title_fullStr | Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting |
title_full_unstemmed | Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting |
title_short | Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting |
title_sort | mechanistic target of rapamycin (mtor) in the cancer setting |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025555/ https://www.ncbi.nlm.nih.gov/pubmed/29848950 http://dx.doi.org/10.3390/cancers10060168 |
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