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Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting

This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special i...

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Detalles Bibliográficos
Autores principales: Murray, James T., Tee, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025555/
https://www.ncbi.nlm.nih.gov/pubmed/29848950
http://dx.doi.org/10.3390/cancers10060168
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author Murray, James T.
Tee, Andrew R.
author_facet Murray, James T.
Tee, Andrew R.
author_sort Murray, James T.
collection PubMed
description This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special issue also describes a wider array of mTOR-driven biological processes that cancer cells benefit from, including autophagy, cell cycle control, metabolic transformation, angiogenic signaling, and anabolic processes such as nucleotide biosynthesis and ribosomal biogenesis. Other areas of mTOR signaling covered in these reviews delve into cell migration, inflammation, and regulation of transcription factors linked to cancer progression.
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spelling pubmed-60255552018-07-09 Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting Murray, James T. Tee, Andrew R. Cancers (Basel) Editorial This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special issue also describes a wider array of mTOR-driven biological processes that cancer cells benefit from, including autophagy, cell cycle control, metabolic transformation, angiogenic signaling, and anabolic processes such as nucleotide biosynthesis and ribosomal biogenesis. Other areas of mTOR signaling covered in these reviews delve into cell migration, inflammation, and regulation of transcription factors linked to cancer progression. MDPI 2018-05-30 /pmc/articles/PMC6025555/ /pubmed/29848950 http://dx.doi.org/10.3390/cancers10060168 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Murray, James T.
Tee, Andrew R.
Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
title Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
title_full Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
title_fullStr Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
title_full_unstemmed Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
title_short Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
title_sort mechanistic target of rapamycin (mtor) in the cancer setting
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025555/
https://www.ncbi.nlm.nih.gov/pubmed/29848950
http://dx.doi.org/10.3390/cancers10060168
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