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Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study
There have been few studies investigating interactions of G-protein beta3 subunit (GNB3) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity. The study aims to evaluate joint effects of GNB3 polymorphisms and sodium consumption on the development of hypert...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025596/ https://www.ncbi.nlm.nih.gov/pubmed/29848945 http://dx.doi.org/10.3390/ijerph15061110 |
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author | Chen, Mei-Ling Huang, Tzu-Pi Chen, Tai-Wei Chan, Hsin-Hua Hwang, Bing-Fang |
author_facet | Chen, Mei-Ling Huang, Tzu-Pi Chen, Tai-Wei Chan, Hsin-Hua Hwang, Bing-Fang |
author_sort | Chen, Mei-Ling |
collection | PubMed |
description | There have been few studies investigating interactions of G-protein beta3 subunit (GNB3) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity. The study aims to evaluate joint effects of GNB3 polymorphisms and sodium consumption on the development of hypertension. A cohort-based case-control study was conducted in 2014. There are 233 participants with newly diagnosed hypertension in the case group and 699 participants in the gender-matched control group. The primary outcome is the development of hypertension over a 10-year period. The determinants of hypertension were three genotypes of SNP in GNB3 (TT; CT; and CC) and two dietary salt categories on the basis of the level of sodium consumption representing high (>4800 mg/day) and low-sodium (<2400 mg/day) diets. The development of hypertension increased with participants carrying TT genotype and high-sodium diets comparing with those carrying TC or CC genotype with low-sodium diets (adjusted OR 3.23, 95% CI 1.52–6.83) (Rothman synergy index = 3.79). The study suggests that GNB3 C825T polymorphism may influence the response of the renin-angiotensin system to high-sodium diet. It implies that GNB3 can be served as an easy, inexpensive, and early genetic marker of salt sensitivity to blood pressure. Salt-sensitive individuals should pay more attention to salt intake to reduce cardiovascular morbidity or mortality. |
format | Online Article Text |
id | pubmed-6025596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60255962018-07-16 Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study Chen, Mei-Ling Huang, Tzu-Pi Chen, Tai-Wei Chan, Hsin-Hua Hwang, Bing-Fang Int J Environ Res Public Health Article There have been few studies investigating interactions of G-protein beta3 subunit (GNB3) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity. The study aims to evaluate joint effects of GNB3 polymorphisms and sodium consumption on the development of hypertension. A cohort-based case-control study was conducted in 2014. There are 233 participants with newly diagnosed hypertension in the case group and 699 participants in the gender-matched control group. The primary outcome is the development of hypertension over a 10-year period. The determinants of hypertension were three genotypes of SNP in GNB3 (TT; CT; and CC) and two dietary salt categories on the basis of the level of sodium consumption representing high (>4800 mg/day) and low-sodium (<2400 mg/day) diets. The development of hypertension increased with participants carrying TT genotype and high-sodium diets comparing with those carrying TC or CC genotype with low-sodium diets (adjusted OR 3.23, 95% CI 1.52–6.83) (Rothman synergy index = 3.79). The study suggests that GNB3 C825T polymorphism may influence the response of the renin-angiotensin system to high-sodium diet. It implies that GNB3 can be served as an easy, inexpensive, and early genetic marker of salt sensitivity to blood pressure. Salt-sensitive individuals should pay more attention to salt intake to reduce cardiovascular morbidity or mortality. MDPI 2018-05-30 2018-06 /pmc/articles/PMC6025596/ /pubmed/29848945 http://dx.doi.org/10.3390/ijerph15061110 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Mei-Ling Huang, Tzu-Pi Chen, Tai-Wei Chan, Hsin-Hua Hwang, Bing-Fang Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study |
title | Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study |
title_full | Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study |
title_fullStr | Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study |
title_full_unstemmed | Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study |
title_short | Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study |
title_sort | interactions of genes and sodium intake on the development of hypertension: a cohort-based case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025596/ https://www.ncbi.nlm.nih.gov/pubmed/29848945 http://dx.doi.org/10.3390/ijerph15061110 |
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