Cargando…

Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics

For patients with metastatic pancreatic cancer that are not eligible for surgery, signal-targeted therapies have so far failed to significantly improve survival. These therapeutic options have been tested in phase II/III clinical trials mostly in combination with the reference treatment gemcitabine....

Descripción completa

Detalles Bibliográficos
Autores principales:	Cintas, Célia, Douché, Thibaut, Therville, Nicole, Arcucci, Silvia, Ramos-Delgado, Fernanda, Basset, Céline, Thibault, Benoît, Guillermet-Guibert, Julie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025626/ https://www.ncbi.nlm.nih.gov/pubmed/29865155 http://dx.doi.org/10.3390/cancers10060174

Ejemplares similares

Experimental pancreatic cancer develops in soft pancreas: novel leads for an individualized diagnosis by ultrafast elasticity imaging
por: Therville, Nicole, et al.
Publicado: (2019)

Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
por: Thibault, Benoit, et al.
Publicado: (2021)

Targeting Class I-II-III PI3Ks in Cancer Therapy: Recent Advances in Tumor Biology and Preclinical Research
por: Thibault, Benoît, et al.
Publicado: (2023)

Heterogeneity of Phosphatidylinositol-3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin Activation in Cancer: Is PI3K Isoform Specificity Important?
por: Cintas, Célia, et al.
Publicado: (2018)

Transducing compressive forces into cellular outputs in cancer and beyond
por: Schmitter, Céline, et al.
Publicado: (2023)

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α
por: Baer, Romain, et al.
Publicado: (2014)

Cell wall proteomic datasets of stems and leaves of Brachypodium distachyon
por: Douché, Thibaut, et al.
Publicado: (2021)

Pancreatic preneoplastic lesions plasma signatures and biomarkers based on proteome profiling of mouse models
por: Ligat, Laetitia, et al.
Publicado: (2015)

Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance
por: Le Naour, Augustin, et al.
Publicado: (2018)

Restoring hemidesmosomes to prevent cancer cell invasiveness
por: Pyronnet, S, et al.
Publicado: (2013)

Paclitaxel induces lymphatic endothelial cells autophagy to promote metastasis
por: Zamora, Audrey, et al.
Publicado: (2019)

CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana highlighted by proteomics, molecular and biochemical studies
por: Epelboin, Yanouk, et al.
Publicado: (2021)

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
por: Berenjeno, Inma M., et al.
Publicado: (2012)

Proteome remodelling by the stress sigma factor RpoS/σ(S) in Salmonella: identification of small proteins and evidence for post-transcriptional regulation
por: Lago, Magali, et al.
Publicado: (2017)

Quality standards in proteomics research facilities: Common standards and quality procedures are essential for proteomics facilities and their users
por: Chiva, Cristina, et al.
Publicado: (2021)

Loss of p27(Kip1) promotes metaplasia in the pancreas via the regulation of Sox9 expression
por: Jeannot, Pauline, et al.
Publicado: (2015)

Comparison of a human neuronal model proteome upon Japanese encephalitis or West Nile Virus infection and potential role of mosquito saliva in neuropathogenesis
por: Besson, Benoit, et al.
Publicado: (2020)

Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates
por: Bouchez, Valérie, et al.
Publicado: (2017)

RNase E and HupB dynamics foster mycobacterial cell homeostasis and fitness
por: Griego, Anna, et al.
Publicado: (2022)

Proteomic Analysis Uncovers Measles Virus Protein C Interaction With p65–iASPP Protein Complex
por: Meignié, Alice, et al.
Publicado: (2021)

Feasibility of comprehensive genotyping specimens from radial endobronchial ultrasonography and electromagnetic navigation bronchoscopy
por: Robin, Maxime, et al.
Publicado: (2021)

Liquid Biopsy of Non-Plasma Body Fluids in Non-Small Cell Lung Cancer: Look Closer to the Tumor!
por: Durin, Lucile, et al.
Publicado: (2020)

Cell wall proteome of sugarcane stems: comparison of a destructive and a non-destructive extraction method showed differences in glycoside hydrolases and peroxidases
por: Calderan-Rodrigues, Maria Juliana, et al.
Publicado: (2016)

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
por: Soler, Adriana, et al.
Publicado: (2013)

Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development
por: Chaves-Almagro, Carline, et al.
Publicado: (2022)

Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS(G12D)-driven Pancreatic Tumorigenesis
por: Chuvin, Nicolas, et al.
Publicado: (2017)

The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro
por: Voegele, Alexis, et al.
Publicado: (2019)

Loss of CorA, the primary magnesium transporter of Salmonella, is alleviated by MgtA and PhoP-dependent compensatory mechanisms
por: Metaane, Selma, et al.
Publicado: (2023)

Production of Multiple Brain-Like Ganglioside Species Is Dispensable for Fas-Induced Apoptosis of Lymphoid Cells
por: Popa, Iuliana, et al.
Publicado: (2011)

Proteomics: Back to the future
por: Roncada, Paola, et al.
Publicado: (2016)

The Resident Medical Officer of the Future
Publicado: (1912)

The Future Tuberculosis Institution Resident
Publicado: (1913)

Le CERN se dévoile en cinquante lieux
por: Guillermet, A
Publicado: (2004)

Proteomics in Pancreatic Cancer Research
por: Geng, Ruihui, et al.
Publicado: (2011)

Ablation in Pancreatic Cancer: Past, Present and Future
por: Narayanan, Govindarajan, et al.
Publicado: (2021)

Are Glucosylceramide-Related Sphingolipids Involved in the Increased Risk for Cancer in Gaucher Disease Patients? Review and Hypotheses
por: Dubot, Patricia, et al.
Publicado: (2020)

The Urology Residency Program in Israel—Results of a Residents Survey and Insights for the Future
por: Lavi, Arnon, et al.
Publicado: (2017)

Future paths in psychopharmacology 
por: Thibaut, Florence
Publicado: (2019)

Current and future applications of liquid biopsy in nonsmall cell lung cancer from early to advanced stages
por: Guibert, Nicolas, et al.
Publicado: (2020)

A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
por: Maulat, Charlotte, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3tqj2cn64fsc2bd17fldv1k383