In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself

BACKGROUND: Loss of PTEN is involved in tumor progression of several tumor entities including renal cell carcinoma (RCC). During the translation process PTEN generates a number of splice variants, including PTEN-Δ. We analyzed the impact of PTEN-Δ in RCC progression. METHODS: In specimens of RCC pat...

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Detalles Bibliográficos
Autores principales: Breuksch, Ines, Welter, Jonas, Bauer, Heide-Katharina, Enklaar, Thorsten, Frees, Sebastian, Thüroff, Joachim W., Hasenburg, Annette, Prawitt, Dirk, Brenner, Walburgis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025732/
https://www.ncbi.nlm.nih.gov/pubmed/29954386
http://dx.doi.org/10.1186/s12964-018-0247-9

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