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Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation

Because of increased use of cell phones, the purpose of this study was to investigation of the oxidative damage caused by electromagnetic radiation (EMR) emitted by cell phones and histological and morphometrical determination of the possible protective role of folic acid (FA) in preventing the detr...

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Autores principales: Deniz, Ömür Gülsüm, Kıvrak, Elfide Gizem, Kaplan, Arife Ahsen, Altunkaynak, Berrin Zuhal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025785/
https://www.ncbi.nlm.nih.gov/pubmed/30023255
http://dx.doi.org/10.1016/j.jmau.2017.06.001
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author Deniz, Ömür Gülsüm
Kıvrak, Elfide Gizem
Kaplan, Arife Ahsen
Altunkaynak, Berrin Zuhal
author_facet Deniz, Ömür Gülsüm
Kıvrak, Elfide Gizem
Kaplan, Arife Ahsen
Altunkaynak, Berrin Zuhal
author_sort Deniz, Ömür Gülsüm
collection PubMed
description Because of increased use of cell phones, the purpose of this study was to investigation of the oxidative damage caused by electromagnetic radiation (EMR) emitted by cell phones and histological and morphometrical determination of the possible protective role of folic acid (FA) in preventing the detrimental effects of EMR on the kidney. Twenty-four adult male Wistar albino rats were divided into control (Cont), EMR, EMR + FA and FA groups, each containing six rats. The EMR and EMR + FA groups were exposed to EMR for 60 min a day over a period of 21 days, while no EMR exposure was applied to the Cont and FA groups. The source of the EMR was an EMR device which emits a digital signal producing 900-MHz frequency radiation. The generator connected to a one-monopole antenna was used in this study and the rats were placed in the plexiglass restrainer at an equal distance from the monopole antenna. Following the experimental period, and after tissue processing, a physical disector-Cavalieri method combination was applied to the sections. The mean volume of the cortex, medulla, proximal and distal tubules increased significantly in the EMR groups compared to the Cont group (p < 0.01). Contrarily, the total number of glomeruli in the EMR group decreased compared to the Cont group (p < 0.01). The protective effects of FA was observed in the kidney (p < 0.05). In conclusion, the 900-MHz EMR leads to kidney damage. FA may exhibit a protective effect against the adverse effects of EMR exposure in terms of the total number of glomeruli.
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spelling pubmed-60257852018-07-18 Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation Deniz, Ömür Gülsüm Kıvrak, Elfide Gizem Kaplan, Arife Ahsen Altunkaynak, Berrin Zuhal J Microsc Ultrastruct Original Article Because of increased use of cell phones, the purpose of this study was to investigation of the oxidative damage caused by electromagnetic radiation (EMR) emitted by cell phones and histological and morphometrical determination of the possible protective role of folic acid (FA) in preventing the detrimental effects of EMR on the kidney. Twenty-four adult male Wistar albino rats were divided into control (Cont), EMR, EMR + FA and FA groups, each containing six rats. The EMR and EMR + FA groups were exposed to EMR for 60 min a day over a period of 21 days, while no EMR exposure was applied to the Cont and FA groups. The source of the EMR was an EMR device which emits a digital signal producing 900-MHz frequency radiation. The generator connected to a one-monopole antenna was used in this study and the rats were placed in the plexiglass restrainer at an equal distance from the monopole antenna. Following the experimental period, and after tissue processing, a physical disector-Cavalieri method combination was applied to the sections. The mean volume of the cortex, medulla, proximal and distal tubules increased significantly in the EMR groups compared to the Cont group (p < 0.01). Contrarily, the total number of glomeruli in the EMR group decreased compared to the Cont group (p < 0.01). The protective effects of FA was observed in the kidney (p < 0.05). In conclusion, the 900-MHz EMR leads to kidney damage. FA may exhibit a protective effect against the adverse effects of EMR exposure in terms of the total number of glomeruli. Medknow Publications & Media Pvt Ltd 2017 2017-06-17 /pmc/articles/PMC6025785/ /pubmed/30023255 http://dx.doi.org/10.1016/j.jmau.2017.06.001 Text en Copyright: © 2017 Saudi Society of Microscopes http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Deniz, Ömür Gülsüm
Kıvrak, Elfide Gizem
Kaplan, Arife Ahsen
Altunkaynak, Berrin Zuhal
Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation
title Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation
title_full Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation
title_fullStr Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation
title_full_unstemmed Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation
title_short Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation
title_sort effects of folic acid on rat kidney exposed to 900 mhz electromagnetic radiation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025785/
https://www.ncbi.nlm.nih.gov/pubmed/30023255
http://dx.doi.org/10.1016/j.jmau.2017.06.001
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