Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington’s disease patients

Huntington’s disease (HD) is a progressive neurodegenerative disorder primarily affecting the basal ganglia and is caused by expanded CAG repeats in the huntingtin gene. Except for CAG sizing, mitochondrial and nuclear DNA (mtDNA and nDNA) parameters have not yet proven to be representative biomarke...

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Detalles Bibliográficos
Autores principales: Askeland, Georgina, Dosoudilova, Zaneta, Rodinova, Marie, Klempir, Jiri, Liskova, Irena, Kuśnierczyk, Anna, Bjørås, Magnar, Nesse, Gaute, Klungland, Arne, Hansikova, Hana, Eide, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026140/
https://www.ncbi.nlm.nih.gov/pubmed/29959348
http://dx.doi.org/10.1038/s41598-018-27985-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026140/
https://www.ncbi.nlm.nih.gov/pubmed/29959348
http://dx.doi.org/10.1038/s41598-018-27985-y

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