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Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington’s disease patients
Huntington’s disease (HD) is a progressive neurodegenerative disorder primarily affecting the basal ganglia and is caused by expanded CAG repeats in the huntingtin gene. Except for CAG sizing, mitochondrial and nuclear DNA (mtDNA and nDNA) parameters have not yet proven to be representative biomarke...
Autores principales: | Askeland, Georgina, Dosoudilova, Zaneta, Rodinova, Marie, Klempir, Jiri, Liskova, Irena, Kuśnierczyk, Anna, Bjørås, Magnar, Nesse, Gaute, Klungland, Arne, Hansikova, Hana, Eide, Lars |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026140/ https://www.ncbi.nlm.nih.gov/pubmed/29959348 http://dx.doi.org/10.1038/s41598-018-27985-y |
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