Conformation-dependent binding of a Tetrastatin peptide to α(v)β(3) integrin decreases melanoma progression through FAK/PI(3)K/Akt pathway inhibition

Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma ce...

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Detalles Bibliográficos
Autores principales: Lambert, Eléonore, Fuselier, Eloïse, Ramont, Laurent, Brassart, Bertrand, Dukic, Sylvain, Oudart, Jean-Baptiste, Dupont-Deshorgue, Aurélie, Sellier, Christèle, Machado, Carine, Dauchez, Manuel, Monboisse, Jean-Claude, Maquart, François-Xavier, Baud, Stéphanie, Brassart-Pasco, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026150/
https://www.ncbi.nlm.nih.gov/pubmed/29959360
http://dx.doi.org/10.1038/s41598-018-28003-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026150/
https://www.ncbi.nlm.nih.gov/pubmed/29959360
http://dx.doi.org/10.1038/s41598-018-28003-x

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