1-Methyl-D-tryptophan Reduces Tumor CD133(+) cells, Wnt/β-catenin and NF-κβp65 while Enhances Lymphocytes NF-κβ2, STAT3, and STAT4 Pathways in Murine Pancreatic Adenocarcinoma

1-Methyl-D-tryptophan (1-MT) is extensively utilized in preclinical trials to deplete indoleamine 2,3-dioxigenase (IDO) activity and kynurenine pathway. Since IDO related signaling pathways aren’t well understood, some clinical reports affirmed IDO inhibiting therapeutic significance. Therefore, we...

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Detalles Bibliográficos
Autores principales: Alahdal, Murad, Xing, Yun, Tang, Tingting, Liang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026162/
https://www.ncbi.nlm.nih.gov/pubmed/29959375
http://dx.doi.org/10.1038/s41598-018-28238-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026162/
https://www.ncbi.nlm.nih.gov/pubmed/29959375
http://dx.doi.org/10.1038/s41598-018-28238-8

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