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Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B

The Na(+)–K(+)–2Cl(−) cotransporter NKCC1 plays a role in neuronal Cl(−) homeostasis secretion and represents a target for brain pathologies with altered NKCC1 function. Two main variants of NKCC1 have been identified: a full-length NKCC1 transcript (NKCC1A) and a shorter splice variant (NKCC1B) tha...

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Detalles Bibliográficos
Autores principales:	Hampel, Philip, Römermann, Kerstin, MacAulay, Nanna, Löscher, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026185/ https://www.ncbi.nlm.nih.gov/pubmed/29959396 http://dx.doi.org/10.1038/s41598-018-27995-w

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