The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Epstein–Barr virus (EBV) can infect cells in latent and lytic period and cause serious disease. Epstein–Barr virus nuclear antigen 1 (EBNA1) is essential for the maintenance of the EBV DNA episome, replication and transcription. 2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat...

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Detalles Bibliográficos
Autores principales: Wang, Huan, Bu, Lang, Wang, Chao, Zhang, Yaqian, Zhou, Heng, Zhang, Xi, Guo, Wei, Long, Cong, Guo, Deyin, Sun, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026193/
https://www.ncbi.nlm.nih.gov/pubmed/29959331
http://dx.doi.org/10.1038/s41419-018-0779-3

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