Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient

Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired inn...

Descripción completa

Detalles Bibliográficos
Autores principales: Workum, Jessica D., de Jong, Suzanne W., Gresnigt, Mark S., Becker, Katharina L., Pickkers, Peter, van de Veerdonk, Frank L., Heijdra, Yvonne F., Kolwijck, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026298/
https://www.ncbi.nlm.nih.gov/pubmed/29984147
http://dx.doi.org/10.1016/j.mmcr.2018.03.002
_version_ 1783336414970118144
author Workum, Jessica D.
de Jong, Suzanne W.
Gresnigt, Mark S.
Becker, Katharina L.
Pickkers, Peter
van de Veerdonk, Frank L.
Heijdra, Yvonne F.
Kolwijck, Eva
author_facet Workum, Jessica D.
de Jong, Suzanne W.
Gresnigt, Mark S.
Becker, Katharina L.
Pickkers, Peter
van de Veerdonk, Frank L.
Heijdra, Yvonne F.
Kolwijck, Eva
author_sort Workum, Jessica D.
collection PubMed
description Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsiveness to antibiotics and especially a suggestive CT-scan should trigger the clinician to consider diseases caused by Aspergillus.
format Online
Article
Text
id pubmed-6026298
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-60262982018-07-06 Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient Workum, Jessica D. de Jong, Suzanne W. Gresnigt, Mark S. Becker, Katharina L. Pickkers, Peter van de Veerdonk, Frank L. Heijdra, Yvonne F. Kolwijck, Eva Med Mycol Case Rep Case Report Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsiveness to antibiotics and especially a suggestive CT-scan should trigger the clinician to consider diseases caused by Aspergillus. Elsevier 2018-03-07 /pmc/articles/PMC6026298/ /pubmed/29984147 http://dx.doi.org/10.1016/j.mmcr.2018.03.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Workum, Jessica D.
de Jong, Suzanne W.
Gresnigt, Mark S.
Becker, Katharina L.
Pickkers, Peter
van de Veerdonk, Frank L.
Heijdra, Yvonne F.
Kolwijck, Eva
Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
title Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
title_full Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
title_fullStr Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
title_full_unstemmed Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
title_short Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
title_sort microbiological and immunological characteristics of a lethal pulmonary aspergillus niger infection in a non-neutropenic patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026298/
https://www.ncbi.nlm.nih.gov/pubmed/29984147
http://dx.doi.org/10.1016/j.mmcr.2018.03.002
work_keys_str_mv AT workumjessicad microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient
AT dejongsuzannew microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient
AT gresnigtmarks microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient
AT beckerkatharinal microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient
AT pickkerspeter microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient
AT vandeveerdonkfrankl microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient
AT heijdrayvonnef microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient
AT kolwijckeva microbiologicalandimmunologicalcharacteristicsofalethalpulmonaryaspergillusnigerinfectioninanonneutropenicpatient

Ejemplares similares