Cargando…

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive disease with colonic dysfunction appearing in the prodromal stage and lasting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Qian-Qian, Haikal, Caroline, Li, Wen, Li, Ming-Tao, Wang, Zhan-You, Li, Jia-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026335/ https://www.ncbi.nlm.nih.gov/pubmed/29988485 http://dx.doi.org/10.1186/s40035-018-0118-8

Ejemplares similares

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
por: Wu, Jia-Zhen, et al.
Publicado: (2019)

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
por: George, Sonia, et al.
Publicado: (2015)

The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation
por: Haikal, Caroline, et al.
Publicado: (2021)

Blood Plasma of Patients with Parkinson's Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity
por: Wang, Peng, et al.
Publicado: (2016)

Cervical skin denervation associates with alpha‐synuclein aggregates in Parkinson disease
por: Melli, Giorgia, et al.
Publicado: (2018)

Parkinson’s Disease: A Nanotheranostic Approach Targeting Alpha-Synuclein Aggregation
por: Zoey, Fong LaiGuan, et al.
Publicado: (2021)

Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
por: Hou, Kaiying, et al.
Publicado: (2023)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Combined measure of salivary alpha-synuclein species as diagnostic biomarker for Parkinson’s disease
por: Angius, Fabrizio, et al.
Publicado: (2023)

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson’s Disease
por: Wan, Oi Wan, et al.
Publicado: (2012)

Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease
por: Canerina-Amaro, Ana, et al.
Publicado: (2019)

Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism
por: Osterberg, Valerie R., et al.
Publicado: (2015)

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
por: Cooper, J Mark, et al.
Publicado: (2014)

RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy
por: Han, Jung-Youn, et al.
Publicado: (2020)

Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC
por: Han, Jung-Youn, et al.
Publicado: (2021)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism
por: Weston, Leah J., et al.
Publicado: (2022)

Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson’s disease
por: de Oliveira, Guilherme A. P., et al.
Publicado: (2019)

Alpha-Synuclein Aggregation Pathway in Parkinson’s Disease: Current Status and Novel Therapeutic Approaches
por: Vidović, Marija, et al.
Publicado: (2022)

Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease
por: Yoo, Hajung, et al.
Publicado: (2022)

Retinal alpha-synuclein accumulation correlates with retinal dysfunction and structural thinning in the A53T mouse model of Parkinson’s disease
por: Tran, Katie K. N., et al.
Publicado: (2023)

Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
por: Earls, Rachael H., et al.
Publicado: (2019)

Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson’s disease
por: Ross, Alysia, et al.
Publicado: (2020)

Temperature-Dependent Structural Changes of Parkinson's Alpha-Synuclein Reveal the Role of Pre-Existing Oligomers in Alpha-Synuclein Fibrillization
por: Ariesandi, Winny, et al.
Publicado: (2013)

Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs
por: Latawiec, Diane, et al.
Publicado: (2010)

Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
por: Torpey, James H., et al.
Publicado: (2020)

Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease
por: Zhou, Wenbo, et al.
Publicado: (2017)

Microbiome changes: an indicator of Parkinson’s disease?
por: Haikal, Caroline, et al.
Publicado: (2019)

Transmission of alpha-synuclein in Parkinson’s disease
por: Lee, Virginia M-Y
Publicado: (2013)

Alpha-synuclein spreading in Parkinson’s disease
por: Recasens, Ariadna, et al.
Publicado: (2014)

MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
por: Geng, Lu, et al.
Publicado: (2023)

The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation
por: Gustavsson, Nadja, et al.
Publicado: (2021)

The Effect of Aggregated Alpha Synuclein on Synaptic and Axonal Proteins in Parkinson’s Disease—A Systematic Review
por: Murphy, Jennifer, et al.
Publicado: (2022)

Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology
por: Ra, Eun A., et al.
Publicado: (2023)

Desulfovibrio bacteria enhance alpha-synuclein aggregation in a Caenorhabditis elegans model of Parkinson’s disease
por: Huynh, Vy A., et al.
Publicado: (2023)

Editorial: Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease
por: Li, Puyu, et al.
Publicado: (2021)

Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice
por: Liu, Yan, et al.
Publicado: (2014)

Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy
por: Wan, Tengfei, et al.
Publicado: (2021)

Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice
por: Mendritzki, Sonja, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ddb8kiemf2qagqb99tmqpvluc4