Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used...

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Autores principales: van Stee, Mariël F., de Graaf, Albert A., Groen, Albert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026339/
https://www.ncbi.nlm.nih.gov/pubmed/29960584
http://dx.doi.org/10.1186/s12933-018-0738-4
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author van Stee, Mariël F.
de Graaf, Albert A.
Groen, Albert K.
author_facet van Stee, Mariël F.
de Graaf, Albert A.
Groen, Albert K.
author_sort van Stee, Mariël F.
collection PubMed
description Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.
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spelling pubmed-60263392018-07-09 Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy van Stee, Mariël F. de Graaf, Albert A. Groen, Albert K. Cardiovasc Diabetol Review Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed. BioMed Central 2018-06-30 /pmc/articles/PMC6026339/ /pubmed/29960584 http://dx.doi.org/10.1186/s12933-018-0738-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
van Stee, Mariël F.
de Graaf, Albert A.
Groen, Albert K.
Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
title Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
title_full Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
title_fullStr Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
title_full_unstemmed Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
title_short Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
title_sort actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026339/
https://www.ncbi.nlm.nih.gov/pubmed/29960584
http://dx.doi.org/10.1186/s12933-018-0738-4
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