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Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience

AIM: Our main objectives were to evaluate the influence of two-year proton pump inhibitors (PPI) therapy in patients with Barrett’s oesophagus on its length, in both types, short and long segment. METHODS: In this single-centre, prospective interventional controlled study were analysed data collecte...

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Autores principales: Gashi, Zaim, Bahtiri, Elton, Gashi, Arjeta, Sherifi, Fadil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026409/
https://www.ncbi.nlm.nih.gov/pubmed/29983798
http://dx.doi.org/10.3889/oamjms.2018.232
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author Gashi, Zaim
Bahtiri, Elton
Gashi, Arjeta
Sherifi, Fadil
author_facet Gashi, Zaim
Bahtiri, Elton
Gashi, Arjeta
Sherifi, Fadil
author_sort Gashi, Zaim
collection PubMed
description AIM: Our main objectives were to evaluate the influence of two-year proton pump inhibitors (PPI) therapy in patients with Barrett’s oesophagus on its length, in both types, short and long segment. METHODS: In this single-centre, prospective interventional controlled study were analysed data collected prospectively over two years from patients with Barrett’s oesophagus diagnosed by endoscopy. Patients who received continuous proton pump inhibitors (PPI) for 2 years were included. At each patient visit symptoms were recorded, and at each endoscopy, the length of Barrett’s oesophagus (BE) was measured. Biopsies were taken along the length of the oesophagus at intervals of 1 cm. In total, 50 patients with Barrett’s oesophagus were included in the study: 10 of whom had long-segment Barrett’s oesophagus, and 40 patients had short-segment Barrett’s oesophagus. The mean number of endoscopies performed was 3 per patient. RESULTS: The length of Barrett’s esophagus (BE) was influenced by PPI therapy: Circumferential extension in BE patients short-segment Barrett’s esophagus (SSBE) (before treatment was 1.5 cm and after treatment was 0.8 cm Maximum proximal extension in SSBE group before treatment was 2.3 cm (SD ± 1.1 cm), and 1.1 cm (SD ± 0.9 cm), respectively. Squamous islands were detected in 25% of patients examined after 2 years on PPIs. CONCLUSIONS: PPIs achieve a reduction to the length of Barrett’s oesophagus, in both types, and the development of squamous islands is commonly associated with their use.
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spelling pubmed-60264092018-07-06 Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience Gashi, Zaim Bahtiri, Elton Gashi, Arjeta Sherifi, Fadil Open Access Maced J Med Sci Clinical Science AIM: Our main objectives were to evaluate the influence of two-year proton pump inhibitors (PPI) therapy in patients with Barrett’s oesophagus on its length, in both types, short and long segment. METHODS: In this single-centre, prospective interventional controlled study were analysed data collected prospectively over two years from patients with Barrett’s oesophagus diagnosed by endoscopy. Patients who received continuous proton pump inhibitors (PPI) for 2 years were included. At each patient visit symptoms were recorded, and at each endoscopy, the length of Barrett’s oesophagus (BE) was measured. Biopsies were taken along the length of the oesophagus at intervals of 1 cm. In total, 50 patients with Barrett’s oesophagus were included in the study: 10 of whom had long-segment Barrett’s oesophagus, and 40 patients had short-segment Barrett’s oesophagus. The mean number of endoscopies performed was 3 per patient. RESULTS: The length of Barrett’s esophagus (BE) was influenced by PPI therapy: Circumferential extension in BE patients short-segment Barrett’s esophagus (SSBE) (before treatment was 1.5 cm and after treatment was 0.8 cm Maximum proximal extension in SSBE group before treatment was 2.3 cm (SD ± 1.1 cm), and 1.1 cm (SD ± 0.9 cm), respectively. Squamous islands were detected in 25% of patients examined after 2 years on PPIs. CONCLUSIONS: PPIs achieve a reduction to the length of Barrett’s oesophagus, in both types, and the development of squamous islands is commonly associated with their use. Republic of Macedonia 2018-06-08 /pmc/articles/PMC6026409/ /pubmed/29983798 http://dx.doi.org/10.3889/oamjms.2018.232 Text en Copyright: © 2018 Zaim Gashi, Elton Bahtiri, Arjeta Gashi, Fadil Sherifi http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Clinical Science
Gashi, Zaim
Bahtiri, Elton
Gashi, Arjeta
Sherifi, Fadil
Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience
title Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience
title_full Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience
title_fullStr Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience
title_full_unstemmed Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience
title_short Proton Pump Inhibitors Diminish Barrett’s Esophagus Length: Our Experience
title_sort proton pump inhibitors diminish barrett’s esophagus length: our experience
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026409/
https://www.ncbi.nlm.nih.gov/pubmed/29983798
http://dx.doi.org/10.3889/oamjms.2018.232
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