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Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases

[Image: see text] Introduction: Starch-based materials were designed using a special extrusion die in order to obtain a tube-shaped device for application to salivary duct treatment in the field of endoscopy, i.e., sialendoscopy . Methods: Extrusion process was used to produce starch tubes. Mechanic...

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Autores principales: Velasquez, Diego, Chaunier, Laurent, Guessasma, Sofiane, Faure, Frédéric, Bizeau, Alain, Pavon-Djavid, Graciela, Meddahi-Pellé, Anne, Lourdin, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026526/
https://www.ncbi.nlm.nih.gov/pubmed/29977830
http://dx.doi.org/10.15171/bi.2018.11
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author Velasquez, Diego
Chaunier, Laurent
Guessasma, Sofiane
Faure, Frédéric
Bizeau, Alain
Pavon-Djavid, Graciela
Meddahi-Pellé, Anne
Lourdin, Denis
author_facet Velasquez, Diego
Chaunier, Laurent
Guessasma, Sofiane
Faure, Frédéric
Bizeau, Alain
Pavon-Djavid, Graciela
Meddahi-Pellé, Anne
Lourdin, Denis
author_sort Velasquez, Diego
collection PubMed
description [Image: see text] Introduction: Starch-based materials were designed using a special extrusion die in order to obtain a tube-shaped device for application to salivary duct treatment in the field of endoscopy, i.e., sialendoscopy . Methods: Extrusion process was used to produce starch tubes. Mechanical properties of the dry tube before implantation were determined using an axial compression test. A finite element study was carried out to simulate the behavior of the hydrated tube under external axial pressure. Hydrolysis of these devices in a simulated salivary solution was studied, as well as its glycerol kinetics release. An animal short-term implantation model for salivary ducts was proposed as a feasibility study for starch tube-shaped devices. Results: A continuous production of regular and size-controlled tubes was obtained. The very small diameter obtained, less than 2 mm, corresponds to the requirement of being insertable in a human salivary duct using sialendoscopy guidewire. Finite element analysis showed that the starch tube can still support an external pressure higher than 0.2 MPa without irreversible damage. After 4 days of implantation, the host response is encouraging and the inflammatory response for this type of procedure remains normal. Conclusion: These devices were adapted to sialendoscopic guidewires and able to be implanted in the salivary ducts of pigs. If a longer lasting tube is required, the crystallinity of the starch material should be improved.
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spelling pubmed-60265262018-07-05 Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases Velasquez, Diego Chaunier, Laurent Guessasma, Sofiane Faure, Frédéric Bizeau, Alain Pavon-Djavid, Graciela Meddahi-Pellé, Anne Lourdin, Denis Bioimpacts Original Research [Image: see text] Introduction: Starch-based materials were designed using a special extrusion die in order to obtain a tube-shaped device for application to salivary duct treatment in the field of endoscopy, i.e., sialendoscopy . Methods: Extrusion process was used to produce starch tubes. Mechanical properties of the dry tube before implantation were determined using an axial compression test. A finite element study was carried out to simulate the behavior of the hydrated tube under external axial pressure. Hydrolysis of these devices in a simulated salivary solution was studied, as well as its glycerol kinetics release. An animal short-term implantation model for salivary ducts was proposed as a feasibility study for starch tube-shaped devices. Results: A continuous production of regular and size-controlled tubes was obtained. The very small diameter obtained, less than 2 mm, corresponds to the requirement of being insertable in a human salivary duct using sialendoscopy guidewire. Finite element analysis showed that the starch tube can still support an external pressure higher than 0.2 MPa without irreversible damage. After 4 days of implantation, the host response is encouraging and the inflammatory response for this type of procedure remains normal. Conclusion: These devices were adapted to sialendoscopic guidewires and able to be implanted in the salivary ducts of pigs. If a longer lasting tube is required, the crystallinity of the starch material should be improved. Tabriz University of Medical Sciences 2018 2017-01-14 /pmc/articles/PMC6026526/ /pubmed/29977830 http://dx.doi.org/10.15171/bi.2018.11 Text en © 2018 The Author(s) This work is published by BioImpacts as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Research
Velasquez, Diego
Chaunier, Laurent
Guessasma, Sofiane
Faure, Frédéric
Bizeau, Alain
Pavon-Djavid, Graciela
Meddahi-Pellé, Anne
Lourdin, Denis
Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases
title Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases
title_full Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases
title_fullStr Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases
title_full_unstemmed Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases
title_short Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases
title_sort design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026526/
https://www.ncbi.nlm.nih.gov/pubmed/29977830
http://dx.doi.org/10.15171/bi.2018.11
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