CAT(3), a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O(6)-methylguanine DNA methyltransferase expression

PURPOSE: Glioblastoma multiforme (GBM) is a malignant high-grade glioma with a poor clinical outcome. Temozolomide (TMZ) is the first-line GBM chemotherapy; however, patients commonly develop resistance to its effects. MATERIALS AND METHODS: We investigated the antitumor activity of CAT(3) in TMZ-re...

Descripción completa

Detalles Bibliográficos
Autores principales: Ji, Ming, Wang, Liyuan, Chen, Ju, Xue, Nina, Wang, Chunyang, Lai, Fangfang, Wang, Rubing, Yu, Shishan, Jin, Jing, Chen, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026589/
https://www.ncbi.nlm.nih.gov/pubmed/29983575
http://dx.doi.org/10.2147/OTT.S163535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026589/
https://www.ncbi.nlm.nih.gov/pubmed/29983575
http://dx.doi.org/10.2147/OTT.S163535

Ejemplares similares