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CAT(3), a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O(6)-methylguanine DNA methyltransferase expression

PURPOSE: Glioblastoma multiforme (GBM) is a malignant high-grade glioma with a poor clinical outcome. Temozolomide (TMZ) is the first-line GBM chemotherapy; however, patients commonly develop resistance to its effects. MATERIALS AND METHODS: We investigated the antitumor activity of CAT(3) in TMZ-re...

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Detalles Bibliográficos
Autores principales:	Ji, Ming, Wang, Liyuan, Chen, Ju, Xue, Nina, Wang, Chunyang, Lai, Fangfang, Wang, Rubing, Yu, Shishan, Jin, Jing, Chen, Xiaoguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026589/ https://www.ncbi.nlm.nih.gov/pubmed/29983575 http://dx.doi.org/10.2147/OTT.S163535

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