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Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, suc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Immunologists
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026691/ https://www.ncbi.nlm.nih.gov/pubmed/29984038 http://dx.doi.org/10.4110/in.2018.18.e20 |
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author | Kwon, Oh Chan Kim, Soohyun Hong, Seokchan Lee, Chang-Keun Yoo, Bin Chang, Eun-Ju Kim, Yong-Gil |
author_facet | Kwon, Oh Chan Kim, Soohyun Hong, Seokchan Lee, Chang-Keun Yoo, Bin Chang, Eun-Ju Kim, Yong-Gil |
author_sort | Kwon, Oh Chan |
collection | PubMed |
description | IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis. |
format | Online Article Text |
id | pubmed-6026691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Association of Immunologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-60266912018-07-06 Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis Kwon, Oh Chan Kim, Soohyun Hong, Seokchan Lee, Chang-Keun Yoo, Bin Chang, Eun-Ju Kim, Yong-Gil Immune Netw Review Article IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis. The Korean Association of Immunologists 2018-06-09 /pmc/articles/PMC6026691/ /pubmed/29984038 http://dx.doi.org/10.4110/in.2018.18.e20 Text en Copyright © 2018. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kwon, Oh Chan Kim, Soohyun Hong, Seokchan Lee, Chang-Keun Yoo, Bin Chang, Eun-Ju Kim, Yong-Gil Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis |
title | Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis |
title_full | Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis |
title_fullStr | Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis |
title_full_unstemmed | Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis |
title_short | Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis |
title_sort | role of il-32 gamma on bone metabolism in autoimmune arthritis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026691/ https://www.ncbi.nlm.nih.gov/pubmed/29984038 http://dx.doi.org/10.4110/in.2018.18.e20 |
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