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Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis

IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, suc...

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Detalles Bibliográficos
Autores principales: Kwon, Oh Chan, Kim, Soohyun, Hong, Seokchan, Lee, Chang-Keun, Yoo, Bin, Chang, Eun-Ju, Kim, Yong-Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026691/
https://www.ncbi.nlm.nih.gov/pubmed/29984038
http://dx.doi.org/10.4110/in.2018.18.e20
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author Kwon, Oh Chan
Kim, Soohyun
Hong, Seokchan
Lee, Chang-Keun
Yoo, Bin
Chang, Eun-Ju
Kim, Yong-Gil
author_facet Kwon, Oh Chan
Kim, Soohyun
Hong, Seokchan
Lee, Chang-Keun
Yoo, Bin
Chang, Eun-Ju
Kim, Yong-Gil
author_sort Kwon, Oh Chan
collection PubMed
description IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis.
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spelling pubmed-60266912018-07-06 Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis Kwon, Oh Chan Kim, Soohyun Hong, Seokchan Lee, Chang-Keun Yoo, Bin Chang, Eun-Ju Kim, Yong-Gil Immune Netw Review Article IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis. The Korean Association of Immunologists 2018-06-09 /pmc/articles/PMC6026691/ /pubmed/29984038 http://dx.doi.org/10.4110/in.2018.18.e20 Text en Copyright © 2018. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kwon, Oh Chan
Kim, Soohyun
Hong, Seokchan
Lee, Chang-Keun
Yoo, Bin
Chang, Eun-Ju
Kim, Yong-Gil
Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
title Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
title_full Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
title_fullStr Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
title_full_unstemmed Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
title_short Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
title_sort role of il-32 gamma on bone metabolism in autoimmune arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026691/
https://www.ncbi.nlm.nih.gov/pubmed/29984038
http://dx.doi.org/10.4110/in.2018.18.e20
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