Cargando…

Insights into Membrane Translocation of Protegrin Antimicrobial Peptides by Multistep Molecular Dynamics Simulations

[Image: see text] Protegrin-1 (PG-1) is a cationic arginine-rich antimicrobial peptide. It is widely accepted that PG-1 induces membrane disruption by forming pores that lead to cell death. However, the insertion mechanism for these highly cationic peptides into the hydrophobic membrane environment...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Pin-Kuang, Kaznessis, Yiannis N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026836/
https://www.ncbi.nlm.nih.gov/pubmed/29978143
http://dx.doi.org/10.1021/acsomega.8b00483