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Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration us...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027072/ https://www.ncbi.nlm.nih.gov/pubmed/29890682 http://dx.doi.org/10.3390/pharmaceutics10020070 |
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author | Shirosaki, Yuki Furuse, Motomasa Asano, Takuji Kinoshita, Yoshihiko Kuroiwa, Toshihiko |
author_facet | Shirosaki, Yuki Furuse, Motomasa Asano, Takuji Kinoshita, Yoshihiko Kuroiwa, Toshihiko |
author_sort | Shirosaki, Yuki |
collection | PubMed |
description | Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues. |
format | Online Article Text |
id | pubmed-6027072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60270722018-07-13 Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation Shirosaki, Yuki Furuse, Motomasa Asano, Takuji Kinoshita, Yoshihiko Kuroiwa, Toshihiko Pharmaceutics Article Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues. MDPI 2018-06-08 /pmc/articles/PMC6027072/ /pubmed/29890682 http://dx.doi.org/10.3390/pharmaceutics10020070 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shirosaki, Yuki Furuse, Motomasa Asano, Takuji Kinoshita, Yoshihiko Kuroiwa, Toshihiko Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
title | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
title_full | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
title_fullStr | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
title_full_unstemmed | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
title_short | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
title_sort | skull bone regeneration using chitosan–siloxane porous hybrids—long-term implantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027072/ https://www.ncbi.nlm.nih.gov/pubmed/29890682 http://dx.doi.org/10.3390/pharmaceutics10020070 |
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