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Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation

Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration us...

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Detalles Bibliográficos
Autores principales: Shirosaki, Yuki, Furuse, Motomasa, Asano, Takuji, Kinoshita, Yoshihiko, Kuroiwa, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027072/
https://www.ncbi.nlm.nih.gov/pubmed/29890682
http://dx.doi.org/10.3390/pharmaceutics10020070
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author Shirosaki, Yuki
Furuse, Motomasa
Asano, Takuji
Kinoshita, Yoshihiko
Kuroiwa, Toshihiko
author_facet Shirosaki, Yuki
Furuse, Motomasa
Asano, Takuji
Kinoshita, Yoshihiko
Kuroiwa, Toshihiko
author_sort Shirosaki, Yuki
collection PubMed
description Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues.
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spelling pubmed-60270722018-07-13 Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation Shirosaki, Yuki Furuse, Motomasa Asano, Takuji Kinoshita, Yoshihiko Kuroiwa, Toshihiko Pharmaceutics Article Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues. MDPI 2018-06-08 /pmc/articles/PMC6027072/ /pubmed/29890682 http://dx.doi.org/10.3390/pharmaceutics10020070 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shirosaki, Yuki
Furuse, Motomasa
Asano, Takuji
Kinoshita, Yoshihiko
Kuroiwa, Toshihiko
Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
title Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
title_full Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
title_fullStr Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
title_full_unstemmed Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
title_short Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
title_sort skull bone regeneration using chitosan–siloxane porous hybrids—long-term implantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027072/
https://www.ncbi.nlm.nih.gov/pubmed/29890682
http://dx.doi.org/10.3390/pharmaceutics10020070
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