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Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life
Sonic Hedgehog (Shh) coordinates Zn(2+) in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn(2+) coordination, while mutating residues essential for catalytic activity results in more stable forms of Shh. Th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027127/ https://www.ncbi.nlm.nih.gov/pubmed/29890674 http://dx.doi.org/10.3390/jdb6020012 |