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Efforts to Improve the Seasonal Influenza Vaccine

Influenza viruses infect approximately 20% of the global population annually, resulting in hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) approved antiviral drugs for combating the disease, vaccination remains the best strategy for preventing infection. Due to th...

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Detalles Bibliográficos
Autores principales: Harding, Alfred T., Heaton, Nicholas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027170/
https://www.ncbi.nlm.nih.gov/pubmed/29601497
http://dx.doi.org/10.3390/vaccines6020019
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author Harding, Alfred T.
Heaton, Nicholas S.
author_facet Harding, Alfred T.
Heaton, Nicholas S.
author_sort Harding, Alfred T.
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description Influenza viruses infect approximately 20% of the global population annually, resulting in hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) approved antiviral drugs for combating the disease, vaccination remains the best strategy for preventing infection. Due to the rapid mutation rate of influenza viruses, vaccine formulations need to be updated every year to provide adequate protection. In recent years, a great amount of effort has been focused on the development of a universal vaccine capable of eliciting broadly protective immunity. While universal influenza vaccines clearly have the best potential to provide long-lasting protection against influenza viruses, the timeline for their development, as well as the true universality of protection they afford, remains uncertain. In an attempt to reduce influenza disease burden while universal vaccines are developed and tested, many groups are working on a variety of strategies to improve the efficacy of the standard seasonal vaccine. This review will highlight the different techniques and technologies that have been, or are being, developed to improve the seasonal vaccination efforts against influenza viruses.
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spelling pubmed-60271702018-07-13 Efforts to Improve the Seasonal Influenza Vaccine Harding, Alfred T. Heaton, Nicholas S. Vaccines (Basel) Review Influenza viruses infect approximately 20% of the global population annually, resulting in hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) approved antiviral drugs for combating the disease, vaccination remains the best strategy for preventing infection. Due to the rapid mutation rate of influenza viruses, vaccine formulations need to be updated every year to provide adequate protection. In recent years, a great amount of effort has been focused on the development of a universal vaccine capable of eliciting broadly protective immunity. While universal influenza vaccines clearly have the best potential to provide long-lasting protection against influenza viruses, the timeline for their development, as well as the true universality of protection they afford, remains uncertain. In an attempt to reduce influenza disease burden while universal vaccines are developed and tested, many groups are working on a variety of strategies to improve the efficacy of the standard seasonal vaccine. This review will highlight the different techniques and technologies that have been, or are being, developed to improve the seasonal vaccination efforts against influenza viruses. MDPI 2018-03-30 /pmc/articles/PMC6027170/ /pubmed/29601497 http://dx.doi.org/10.3390/vaccines6020019 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Harding, Alfred T.
Heaton, Nicholas S.
Efforts to Improve the Seasonal Influenza Vaccine
title Efforts to Improve the Seasonal Influenza Vaccine
title_full Efforts to Improve the Seasonal Influenza Vaccine
title_fullStr Efforts to Improve the Seasonal Influenza Vaccine
title_full_unstemmed Efforts to Improve the Seasonal Influenza Vaccine
title_short Efforts to Improve the Seasonal Influenza Vaccine
title_sort efforts to improve the seasonal influenza vaccine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027170/
https://www.ncbi.nlm.nih.gov/pubmed/29601497
http://dx.doi.org/10.3390/vaccines6020019
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