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Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose
Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu(2)(BDC)(2)(DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027177/ https://www.ncbi.nlm.nih.gov/pubmed/29899253 http://dx.doi.org/10.3390/nano8060429 |
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author | Sivasankar, Kulandaivel Rani, Karuppasamy Kohila Wang, Sea-Fue Devasenathipathy, Rajkumar Lin, Chia-Her |
author_facet | Sivasankar, Kulandaivel Rani, Karuppasamy Kohila Wang, Sea-Fue Devasenathipathy, Rajkumar Lin, Chia-Her |
author_sort | Sivasankar, Kulandaivel |
collection | PubMed |
description | Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu(2)(BDC)(2)(DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 μM and 1803 μM (linear range) with good sensitivity (2500 μA mM(−1) cm(−2)). Our glucose sensor also possesses low limits of detection (0.44 μM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose. |
format | Online Article Text |
id | pubmed-6027177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60271772018-07-13 Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose Sivasankar, Kulandaivel Rani, Karuppasamy Kohila Wang, Sea-Fue Devasenathipathy, Rajkumar Lin, Chia-Her Nanomaterials (Basel) Article Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu(2)(BDC)(2)(DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 μM and 1803 μM (linear range) with good sensitivity (2500 μA mM(−1) cm(−2)). Our glucose sensor also possesses low limits of detection (0.44 μM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose. MDPI 2018-06-13 /pmc/articles/PMC6027177/ /pubmed/29899253 http://dx.doi.org/10.3390/nano8060429 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sivasankar, Kulandaivel Rani, Karuppasamy Kohila Wang, Sea-Fue Devasenathipathy, Rajkumar Lin, Chia-Her Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose |
title | Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose |
title_full | Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose |
title_fullStr | Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose |
title_full_unstemmed | Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose |
title_short | Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose |
title_sort | copper nanoparticle and nitrogen doped graphite oxide based biosensor for the sensitive determination of glucose |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027177/ https://www.ncbi.nlm.nih.gov/pubmed/29899253 http://dx.doi.org/10.3390/nano8060429 |
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