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In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases
In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therapeutics to the desired site, reduce peripheral toxicity and control drug release kinetics have been developed. Some of the therapeutics used to treat neurological diseases suffer from poor bioavailabili...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027251/ https://www.ncbi.nlm.nih.gov/pubmed/29601486 http://dx.doi.org/10.3390/pharmaceutics10020040 |
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author | Aderibigbe, Blessing Atim |
author_facet | Aderibigbe, Blessing Atim |
author_sort | Aderibigbe, Blessing Atim |
collection | PubMed |
description | In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therapeutics to the desired site, reduce peripheral toxicity and control drug release kinetics have been developed. Some of the therapeutics used to treat neurological diseases suffer from poor bioavailability. Preclinical reports from several researchers have proven that the delivery of drugs to the brain via the nose-to-brain route using in situ gels holds great promise. However, safety issues on the toxicity of the nasal mucosa, transportation of the drugs to specific brain regions and determination of the required dose are factors that must be considered when designing these gels. This review will be focused on in situ-based gels that are used for the delivery of therapeutics via the nose-to-brain route, preclinical reports and challenges. |
format | Online Article Text |
id | pubmed-6027251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60272512018-07-13 In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases Aderibigbe, Blessing Atim Pharmaceutics Review In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therapeutics to the desired site, reduce peripheral toxicity and control drug release kinetics have been developed. Some of the therapeutics used to treat neurological diseases suffer from poor bioavailability. Preclinical reports from several researchers have proven that the delivery of drugs to the brain via the nose-to-brain route using in situ gels holds great promise. However, safety issues on the toxicity of the nasal mucosa, transportation of the drugs to specific brain regions and determination of the required dose are factors that must be considered when designing these gels. This review will be focused on in situ-based gels that are used for the delivery of therapeutics via the nose-to-brain route, preclinical reports and challenges. MDPI 2018-03-30 /pmc/articles/PMC6027251/ /pubmed/29601486 http://dx.doi.org/10.3390/pharmaceutics10020040 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aderibigbe, Blessing Atim In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases |
title | In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases |
title_full | In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases |
title_fullStr | In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases |
title_full_unstemmed | In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases |
title_short | In Situ-Based Gels for Nose to Brain Delivery for the Treatment of Neurological Diseases |
title_sort | in situ-based gels for nose to brain delivery for the treatment of neurological diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027251/ https://www.ncbi.nlm.nih.gov/pubmed/29601486 http://dx.doi.org/10.3390/pharmaceutics10020040 |
work_keys_str_mv | AT aderibigbeblessingatim insitubasedgelsfornosetobraindeliveryforthetreatmentofneurologicaldiseases |