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Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan

After 26 years, we followed up 7348 participants in a 1979–1984 health screening survey in the Jinzu River basin, the heaviest cadmium-polluted area in Japan. We assessed the associations of cadmium exposure levels and mortality from cancer and renal damage, indicated by records of proteinuria and g...

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Autores principales: Nishijo, Muneko, Nakagawa, Hideaki, Suwazono, Yasushi, Nogawa, Kazuhiro, Sakurai, Masaru, Ishizaki, Masao, Kido, Teruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027272/
https://www.ncbi.nlm.nih.gov/pubmed/29642374
http://dx.doi.org/10.3390/toxics6020023
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author Nishijo, Muneko
Nakagawa, Hideaki
Suwazono, Yasushi
Nogawa, Kazuhiro
Sakurai, Masaru
Ishizaki, Masao
Kido, Teruhiko
author_facet Nishijo, Muneko
Nakagawa, Hideaki
Suwazono, Yasushi
Nogawa, Kazuhiro
Sakurai, Masaru
Ishizaki, Masao
Kido, Teruhiko
author_sort Nishijo, Muneko
collection PubMed
description After 26 years, we followed up 7348 participants in a 1979–1984 health screening survey in the Jinzu River basin, the heaviest cadmium-polluted area in Japan. We assessed the associations of cadmium exposure levels and mortality from cancer and renal damage, indicated by records of proteinuria and glucosuria in the original survey. Mortality risks (hazard ratios) were analyzed using the Cox proportional hazards model, stratified by sex, after adjusting for age, smoking status, and hypertension, as indicated in the original survey records. In men, the adjusted hazard ratio for mortality from lung cancer was significantly lower in individuals residing in an area of historically high cadmium exposure and in subjects with a historical record of proteinuria, glucosuria, and glucoproteinuria. The risk of mortality from prostate cancer was borderline higher in cadmium-exposed men. In women, historical cadmium exposure was not associated with an increased risk of mortality from malignant neoplasms, but the adjusted hazard ratios for death from total malignant neoplasms or from renal and uterine cancers were significantly higher in exposed subjects with a historical record of proteinuria, glucosuria, and glucoproteinuria. These findings suggest that women residing in cadmium-polluted areas who exhibit markers of renal damage may be at risk of dying of cancer.
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spelling pubmed-60272722018-07-13 Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan Nishijo, Muneko Nakagawa, Hideaki Suwazono, Yasushi Nogawa, Kazuhiro Sakurai, Masaru Ishizaki, Masao Kido, Teruhiko Toxics Article After 26 years, we followed up 7348 participants in a 1979–1984 health screening survey in the Jinzu River basin, the heaviest cadmium-polluted area in Japan. We assessed the associations of cadmium exposure levels and mortality from cancer and renal damage, indicated by records of proteinuria and glucosuria in the original survey. Mortality risks (hazard ratios) were analyzed using the Cox proportional hazards model, stratified by sex, after adjusting for age, smoking status, and hypertension, as indicated in the original survey records. In men, the adjusted hazard ratio for mortality from lung cancer was significantly lower in individuals residing in an area of historically high cadmium exposure and in subjects with a historical record of proteinuria, glucosuria, and glucoproteinuria. The risk of mortality from prostate cancer was borderline higher in cadmium-exposed men. In women, historical cadmium exposure was not associated with an increased risk of mortality from malignant neoplasms, but the adjusted hazard ratios for death from total malignant neoplasms or from renal and uterine cancers were significantly higher in exposed subjects with a historical record of proteinuria, glucosuria, and glucoproteinuria. These findings suggest that women residing in cadmium-polluted areas who exhibit markers of renal damage may be at risk of dying of cancer. MDPI 2018-04-06 /pmc/articles/PMC6027272/ /pubmed/29642374 http://dx.doi.org/10.3390/toxics6020023 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nishijo, Muneko
Nakagawa, Hideaki
Suwazono, Yasushi
Nogawa, Kazuhiro
Sakurai, Masaru
Ishizaki, Masao
Kido, Teruhiko
Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan
title Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan
title_full Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan
title_fullStr Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan
title_full_unstemmed Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan
title_short Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan
title_sort cancer mortality in residents of the cadmium-polluted jinzu river basin in toyama, japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027272/
https://www.ncbi.nlm.nih.gov/pubmed/29642374
http://dx.doi.org/10.3390/toxics6020023
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