Adiponectin Signaling Pathways in Liver Diseases

In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different s...

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Detalles Bibliográficos
Autores principales: Gamberi, Tania, Magherini, Francesca, Modesti, Alessandra, Fiaschi, Tania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027295/
https://www.ncbi.nlm.nih.gov/pubmed/29735928
http://dx.doi.org/10.3390/biomedicines6020052
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author Gamberi, Tania
Magherini, Francesca
Modesti, Alessandra
Fiaschi, Tania
author_facet Gamberi, Tania
Magherini, Francesca
Modesti, Alessandra
Fiaschi, Tania
author_sort Gamberi, Tania
collection PubMed
description In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration.
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spelling pubmed-60272952018-07-13 Adiponectin Signaling Pathways in Liver Diseases Gamberi, Tania Magherini, Francesca Modesti, Alessandra Fiaschi, Tania Biomedicines Review In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration. MDPI 2018-05-07 /pmc/articles/PMC6027295/ /pubmed/29735928 http://dx.doi.org/10.3390/biomedicines6020052 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gamberi, Tania
Magherini, Francesca
Modesti, Alessandra
Fiaschi, Tania
Adiponectin Signaling Pathways in Liver Diseases
title Adiponectin Signaling Pathways in Liver Diseases
title_full Adiponectin Signaling Pathways in Liver Diseases
title_fullStr Adiponectin Signaling Pathways in Liver Diseases
title_full_unstemmed Adiponectin Signaling Pathways in Liver Diseases
title_short Adiponectin Signaling Pathways in Liver Diseases
title_sort adiponectin signaling pathways in liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027295/
https://www.ncbi.nlm.nih.gov/pubmed/29735928
http://dx.doi.org/10.3390/biomedicines6020052
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AT magherinifrancesca adiponectinsignalingpathwaysinliverdiseases
AT modestialessandra adiponectinsignalingpathwaysinliverdiseases
AT fiaschitania adiponectinsignalingpathwaysinliverdiseases

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