Cargando…

A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2

Matriptase-2 is a type II transmembrane serine protease and a key regulator of systemic iron homeostasis. Since the activation mechanism and several features of the physiological role of matriptase-2 are not fully understood, there is strong need for analytical tools to perform tasks such as disting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mangold, Martin, Gütschow, Michael, Stirnberg, Marit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027297/ https://www.ncbi.nlm.nih.gov/pubmed/29883401 http://dx.doi.org/10.3390/ph11020049

Ejemplares similares

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach
por: Roydeva, Polya G., et al.
Publicado: (2016)

3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro
por: Pászti-Gere, Erzsébet, et al.
Publicado: (2019)

Detection of Active Matriptase Using a Biotinylated Chloromethyl Ketone Peptide
por: Godiksen, Sine, et al.
Publicado: (2013)

Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1
por: Glotzbach, Bernhard, et al.
Publicado: (2013)

ROS is a master regulator of in vitro matriptase activation
por: Gaymon, Darius O., et al.
Publicado: (2023)

Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
por: Tseng, Chun-Che, et al.
Publicado: (2017)

Decreasing the ratio of matriptase/HAI-1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer
por: Sun, Pengming, et al.
Publicado: (2016)

Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1
por: Yuan, Cai, et al.
Publicado: (2011)

The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells
por: Steiro, Ida, et al.
Publicado: (2022)

Activated matriptase as a target to treat breast cancer with a drug conjugate
por: Rather, Gulam M., et al.
Publicado: (2018)

The role of TMPRSS6/matriptase-2 in iron regulation and anemia
por: Wang, Chia-Yu, et al.
Publicado: (2014)

Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice
por: Krijt, Jan, et al.
Publicado: (2021)

Matriptase Autoactivation Is Tightly Regulated by the Cellular Chemical Environments
por: Wang, Jehng-Kang, et al.
Publicado: (2014)

Differential Subcellular Localization Renders HAI-2 a Matriptase Inhibitor in Breast Cancer Cells but Not in Mammary Epithelial Cells
por: Chang, Hsiang-Hua D., et al.
Publicado: (2015)

Diversity of Matriptase Expression Level and Function in Breast Cancer
por: Welman, Arkadiusz, et al.
Publicado: (2012)

The Impact of Acute Matriptase Inhibition in Hepatic Inflammatory Models
por: Pomothy, Judit, et al.
Publicado: (2016)

Matriptase zymogen supports epithelial development, homeostasis and regeneration
por: Friis, Stine, et al.
Publicado: (2017)

Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28
por: Chen, Li-Mei, et al.
Publicado: (2019)

Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
por: Folgueras, Alicia R., et al.
Publicado: (2018)

Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes
por: Chen, Ya-Wen, et al.
Publicado: (2013)

Inhibition of Matriptase Activity Results in Decreased Intestinal Epithelial Monolayer Integrity In Vitro
por: Pászti-Gere, E., et al.
Publicado: (2015)

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX
por: Ma, Jiajia, et al.
Publicado: (2021)

The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells
por: Wu, Shang-Ru, et al.
Publicado: (2017)

Antithrombin Regulates Matriptase Activity Involved in Plasmin Generation, Syndecan Shedding, and HGF Activation in Keratinocytes
por: Chen, Ya-Wen, et al.
Publicado: (2013)

Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis
por: Drees, Leonard, et al.
Publicado: (2019)

Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity
por: Chiu, Yi-Lin, et al.
Publicado: (2020)

Matriptase processing of APLP1 ectodomain alters its homodimerization
por: Lanchec, Erwan, et al.
Publicado: (2020)

Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis
por: da Silva, Elaine Zayas Marcelino, et al.
Publicado: (2021)

Exosome-Mediated Activation of the Prostasin-Matriptase Serine Protease Cascade in B Lymphoma Cells
por: Chen, Li-Mei, et al.
Publicado: (2023)

Matriptase Deletion Initiates a Sjögren’s Syndrome-Like Disease in Mice
por: Yin, Hongen, et al.
Publicado: (2014)

Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins
por: Wu, Chuan-Jin, et al.
Publicado: (2020)

Matriptase initiates epidermal prokallikrein activation and disease onset in a mouse model of Netherton syndrome
por: Sales, Katiuchia Uzzun, et al.
Publicado: (2010)

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer
por: Zoratti, Gina L., et al.
Publicado: (2016)

Author Correction: The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells
por: Wu, Shang-Ru, et al.
Publicado: (2020)

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
por: Szabo, Roman, et al.
Publicado: (2011)

Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors
por: Sales, Katiuchia Uzzun, et al.
Publicado: (2014)

N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin
por: Lai, Ying-Jung J., et al.
Publicado: (2015)

Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2
por: Chiu, Yi-Lin, et al.
Publicado: (2019)

Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis
por: Gnana-Prakasam, Jaya P., et al.
Publicado: (2014)

Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner
por: Su, Hui Chen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sockh9qq72v0885nqu7351pebn