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Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms

Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known...

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Detalles Bibliográficos
Autores principales: Batie, Michael, del Peso, Luis, Rocha, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027312/
https://www.ncbi.nlm.nih.gov/pubmed/29690561
http://dx.doi.org/10.3390/biomedicines6020047
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author Batie, Michael
del Peso, Luis
Rocha, Sonia
author_facet Batie, Michael
del Peso, Luis
Rocha, Sonia
author_sort Batie, Michael
collection PubMed
description Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.
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spelling pubmed-60273122018-07-13 Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms Batie, Michael del Peso, Luis Rocha, Sonia Biomedicines Review Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia. MDPI 2018-04-22 /pmc/articles/PMC6027312/ /pubmed/29690561 http://dx.doi.org/10.3390/biomedicines6020047 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Batie, Michael
del Peso, Luis
Rocha, Sonia
Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
title Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
title_full Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
title_fullStr Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
title_full_unstemmed Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
title_short Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
title_sort hypoxia and chromatin: a focus on transcriptional repression mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027312/
https://www.ncbi.nlm.nih.gov/pubmed/29690561
http://dx.doi.org/10.3390/biomedicines6020047
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