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Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data

Parkinson’s disease (PD) is one of the most common progressive neurodegenerative diseases. Clinical and epidemiological studies indicate that sex differences, as well as genetic components and ageing, can influence the prevalence, age at onset and symptomatology of PD. This study undertook a systema...

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Autores principales: Mariani, Elisa, Lombardini, Lorenza, Facchin, Federica, Pizzetti, Fabrizio, Frabetti, Flavia, Tarozzi, Andrea, Casadei, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027313/
https://www.ncbi.nlm.nih.gov/pubmed/29799491
http://dx.doi.org/10.3390/genes9060275
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author Mariani, Elisa
Lombardini, Lorenza
Facchin, Federica
Pizzetti, Fabrizio
Frabetti, Flavia
Tarozzi, Andrea
Casadei, Raffaella
author_facet Mariani, Elisa
Lombardini, Lorenza
Facchin, Federica
Pizzetti, Fabrizio
Frabetti, Flavia
Tarozzi, Andrea
Casadei, Raffaella
author_sort Mariani, Elisa
collection PubMed
description Parkinson’s disease (PD) is one of the most common progressive neurodegenerative diseases. Clinical and epidemiological studies indicate that sex differences, as well as genetic components and ageing, can influence the prevalence, age at onset and symptomatology of PD. This study undertook a systematic meta-analysis of substantia nigra microarray data using the Transcriptome Mapper (TRAM) software to integrate and normalize a total of 10 suitable datasets from multiple sources. Four different analyses were performed according to default parameters, to better define the segments differentially expressed between PD patients and healthy controls, when comparing men and women data sets. The results suggest a possible regulation of specific sex-biased systems in PD susceptibility. TRAM software allowed us to highlight the different activation of some genomic regions and loci involved in molecular pathways related to neurodegeneration and neuroinflammatory mechanisms.
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spelling pubmed-60273132018-07-13 Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data Mariani, Elisa Lombardini, Lorenza Facchin, Federica Pizzetti, Fabrizio Frabetti, Flavia Tarozzi, Andrea Casadei, Raffaella Genes (Basel) Article Parkinson’s disease (PD) is one of the most common progressive neurodegenerative diseases. Clinical and epidemiological studies indicate that sex differences, as well as genetic components and ageing, can influence the prevalence, age at onset and symptomatology of PD. This study undertook a systematic meta-analysis of substantia nigra microarray data using the Transcriptome Mapper (TRAM) software to integrate and normalize a total of 10 suitable datasets from multiple sources. Four different analyses were performed according to default parameters, to better define the segments differentially expressed between PD patients and healthy controls, when comparing men and women data sets. The results suggest a possible regulation of specific sex-biased systems in PD susceptibility. TRAM software allowed us to highlight the different activation of some genomic regions and loci involved in molecular pathways related to neurodegeneration and neuroinflammatory mechanisms. MDPI 2018-05-25 /pmc/articles/PMC6027313/ /pubmed/29799491 http://dx.doi.org/10.3390/genes9060275 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mariani, Elisa
Lombardini, Lorenza
Facchin, Federica
Pizzetti, Fabrizio
Frabetti, Flavia
Tarozzi, Andrea
Casadei, Raffaella
Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data
title Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data
title_full Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data
title_fullStr Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data
title_full_unstemmed Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data
title_short Sex-Specific Transcriptome Differences in Substantia Nigra Tissue: A Meta-Analysis of Parkinson’s Disease Data
title_sort sex-specific transcriptome differences in substantia nigra tissue: a meta-analysis of parkinson’s disease data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027313/
https://www.ncbi.nlm.nih.gov/pubmed/29799491
http://dx.doi.org/10.3390/genes9060275
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