Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders

Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and interaction and restricted-repetitive patterns of behavior, interests, or activities. Strong inflammation states are associated with ASD. This inflammatory condition is often linked to immune system dy...

Descripción completa

Detalles Bibliográficos
Autores principales: Siniscalco, Dario, Schultz, Stephen, Brigida, Anna Lisa, Antonucci, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027314/
https://www.ncbi.nlm.nih.gov/pubmed/29867038
http://dx.doi.org/10.3390/ph11020056
_version_ 1783336583068385280
author Siniscalco, Dario
Schultz, Stephen
Brigida, Anna Lisa
Antonucci, Nicola
author_facet Siniscalco, Dario
Schultz, Stephen
Brigida, Anna Lisa
Antonucci, Nicola
author_sort Siniscalco, Dario
collection PubMed
description Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and interaction and restricted-repetitive patterns of behavior, interests, or activities. Strong inflammation states are associated with ASD. This inflammatory condition is often linked to immune system dysfunction. Several cell types are enrolled to trigger and sustain these processes. Neuro-inflammation and neuro-immune abnormalities have now been established in ASD as key factors in its development and maintenance. In this review, we will explore inflammatory conditions, dysfunctions in neuro-immune cross-talk, and immune system treatments in ASD management.
format Online
Article
Text
id pubmed-6027314
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60273142018-07-13 Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders Siniscalco, Dario Schultz, Stephen Brigida, Anna Lisa Antonucci, Nicola Pharmaceuticals (Basel) Review Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and interaction and restricted-repetitive patterns of behavior, interests, or activities. Strong inflammation states are associated with ASD. This inflammatory condition is often linked to immune system dysfunction. Several cell types are enrolled to trigger and sustain these processes. Neuro-inflammation and neuro-immune abnormalities have now been established in ASD as key factors in its development and maintenance. In this review, we will explore inflammatory conditions, dysfunctions in neuro-immune cross-talk, and immune system treatments in ASD management. MDPI 2018-06-04 /pmc/articles/PMC6027314/ /pubmed/29867038 http://dx.doi.org/10.3390/ph11020056 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Siniscalco, Dario
Schultz, Stephen
Brigida, Anna Lisa
Antonucci, Nicola
Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders
title Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders
title_full Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders
title_fullStr Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders
title_full_unstemmed Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders
title_short Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders
title_sort inflammation and neuro-immune dysregulations in autism spectrum disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027314/
https://www.ncbi.nlm.nih.gov/pubmed/29867038
http://dx.doi.org/10.3390/ph11020056
work_keys_str_mv AT siniscalcodario inflammationandneuroimmunedysregulationsinautismspectrumdisorders
AT schultzstephen inflammationandneuroimmunedysregulationsinautismspectrumdisorders
AT brigidaannalisa inflammationandneuroimmunedysregulationsinautismspectrumdisorders
AT antonuccinicola inflammationandneuroimmunedysregulationsinautismspectrumdisorders

Ejemplares similares